Enantioselective total synthesis of (+)-vincamine
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.09.032
Abstract: ABSTRACT A catalytic asymmetric total synthesis of (+)-vincamine is presented. Key features of the synthesis include a Pd-catalyzed enantioselective decarboxylative allylation to form the C20 quaternary stereogenic center and a stereoselective iminium reduction to install… read more here.
Keywords: total synthesis; synthesis vincamine; enantioselective total;
First asymmetric enantioselective total synthesis of phenanthridine alkaloid, (S)-(+)-asiaticumine and its enantiomer
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151278
Abstract: Abstract In this study, the first asymmetric enantioselective total syntheses of (+)-asiaticumine A (2) and its enantiomer were accomplished through a seven-step sequence using the bond formation between the C4a and N5 positions of the… read more here.
Keywords: first asymmetric; asiaticumine enantiomer; enantioselective total; total synthesis ... See more keywords
Enantioselective Total Synthesis of (+)-Pepluanol A.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00961
Abstract: Herein, we report an enantioselective and convergent total synthesis of (+)-pepluanol A, a structurally intriguing Euphorbia diterpenoid natural product featuring a 5/6/7/3-fused tetracyclic skeleton, from known building blocks in 11 steps. The successful strategy relies… read more here.
Keywords: pepluanol; reaction; synthesis pepluanol; enantioselective total ... See more keywords
Shortest Enantioselective Total Syntheses of (+)-Isolaurepinnacin and (+)-Neoisoprelaurefucin
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DOI: 10.1021/acs.orglett.2c01769
Abstract: The shortest enantioselective total syntheses of (+)-isolaurepinnacin and (+)-neoisoprelaurefucin have been accomplished. These syntheses were based on a common parallel synthetic strategy using Prins–Peterson cyclization in their core construction. In only one step, a seven-membered… read more here.
Keywords: shortest enantioselective; total syntheses; isolaurepinnacin neoisoprelaurefucin; syntheses isolaurepinnacin ... See more keywords
Enantioselective Total Synthesis of (-)-Hamigeran F and Its Rearrangement Product.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01997
Abstract: Herein, we report the first enantioselective total synthesis of the highly complex hamigeran diterpenoid (-)-hamigeran F and its rearrangement product. The synthetic strategy features key steps of asymmetric hydrogenation, Horner-Wadsworth-Emmons olefination, and intramolecular Friedel-Crafts acylation… read more here.
Keywords: rearrangement product; hamigeran rearrangement; enantioselective total; total synthesis ... See more keywords
Enantioselective Total Synthesis of (+)-Sieboldine A and Analogues Thereof.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02737
Abstract: An 11-step enantioselective total synthesis of (+)-sieboldine A (1) has been accomplished from (5R)-methylcyclohex-2-en-1-one (16), in which an intramolecular ketone/ester reductive coupling followed by one-pot acidic treatment to quickly construct the unique oxa-spiroacetal and a… read more here.
Keywords: total synthesis; sieboldine analogues; synthesis sieboldine; enantioselective total ... See more keywords
Enantioselective Total Synthesis of Beraprost Using Organocatalyst.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b00134
Abstract: A convergent and enantioselective total synthesis of the most active isomer of beraprost was achieved in 17 pots. A unique tricyclic core in beraprost was synthesized efficiently by utilizing the asymmetric organocatalyst-mediated formal [3 +… read more here.
Keywords: beraprost; enantioselective total; total synthesis; beraprost using ... See more keywords
Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03668
Abstract: A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported. read more here.
Keywords: route analogue; enantioselective total; synthesis cannabinoids; total synthesis ... See more keywords
Enantioselective Total Synthesis of Diocollettines A.
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DOI: 10.1021/acs.orglett.9b01776
Abstract: The first enantioselective total synthesis of diocollettines A was accomplished in only six steps from a known compound. A short and practical synthetic route was disclosed, featuring an intensive investigation of the stereoselective aldol reaction… read more here.
Keywords: total synthesis; synthesis diocollettines; enantioselective total;
Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00047
Abstract: We report the first enantioselective total syntheses of the hasubanan alkaloid (-)-metaphanine and the norhasubanan alkaloid (+)-stephadiamine. Key features of these syntheses include diastereoselective oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction, which… read more here.
Keywords: benzilic acid; type rearrangement; aza benzilic; enantioselective total ... See more keywords
Enantioselective Total Synthesis of (+)-Euphorikanin A.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c04210
Abstract: We disclose the first total synthesis of (+)-euphorikanin A, an ingenane-derived natural product featuring an unprecedented 5/6/7/3-fused tetracyclic skeleton. Key to the approach is a SmI2-mediated ketyl-enoate reaction that leads to the formation of two… read more here.
Keywords: total synthesis; synthesis euphorikanin; enantioselective total; synthesis ... See more keywords