Abstract 2721: Sustained delivery of low-dose anti-CTLA-4 by genetically engineered encapsulated cells to the tumor microenvironment drives tumor response and prolongs survival in a colorectal cancer model
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2721
Abstract: Introduction: Systemic therapy with CTLA-4 blocking antibody (aCTLA-4) restores endogenous antitumor immunity and induces remarkable long-term clinical benefits in patients with melanoma. Yet immune-related side effects remain a major hurdle to extending its label to… read more here.
Keywords: engineered encapsulated; encapsulated cells; tumor; cancer ... See more keywords
Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?
Sign Up to like & getrecommendations! Published in 2023 at "Cell Transplantation"
DOI: 10.1177/09636897231163233
Abstract: Transplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released from an implanted encapsulation device damaged in an accident… read more here.
Keywords: danger acute; cells treatment; encapsulated cells; diabetes danger ... See more keywords