Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones
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DOI: 10.1021/acsmedchemlett.1c00539
Abstract: Venezuelan and eastern equine encephalitis viruses are disease-causing, neuropathic pathogens with no approved treatment options in humans. While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones… read more here.
Keywords: inhibitors via; alphavirus inhibitors; encephalitic alphavirus; piperazinobenzodiazepinones new ... See more keywords
Sequelae and Animal Modeling of Encephalitic Alphavirus Infections
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15020382
Abstract: Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe… read more here.
Keywords: alphavirus infections; encephalitic alphavirus; animal modeling; modeling encephalitic ... See more keywords