Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction.
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DOI: 10.1021/acs.bioconjchem.5c00455
Abstract: Bicyclic peptides, with two cyclic substructures, have emerged as a powerful tool for modulating challenging targets such as protein-protein interactions. Meanwhile, DNA-encoded library technology (DELT) provides a powerful platform for hit discovery. The unity of… read more here.
Keywords: synthesis dna; encoded bicyclic; peptides via; bicyclic peptides ... See more keywords