Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Peptide Science"
DOI: 10.1002/psc.3600
Abstract: Agricultural crops are targeted by various pathogens (fungi, bacteria, and viruses) and pests (herbivorous arthropods). Antimicrobial and insecticidal peptides are increasingly recognized as eco‐friendly tools for crop protection due to their low propensity for resistance… read more here.
Keywords: genetically encoded; protective peptides; crop; encoded libraries ... See more keywords
Design of DNA Encoded Libraries for Medicinal Chemistry.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00356
Abstract: DNA-encoded libraries (DELs) have revolutionized hit identification in drug discovery by offering an accessible, versatile, and cost-effective alternative to traditional high-throughput screening (HTS). This perspective analyzes the results of recent DEL technology (DELT) screens (2020-2025)… read more here.
Keywords: chemistry; design dna; encoded libraries; dna encoded ... See more keywords
Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.
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DOI: 10.1039/d0cc01474e
Abstract: We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible… read more here.
Keywords: phase synthesis; dna encoded; solid phase; synthesis dna ... See more keywords
DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra09889b
Abstract: A DNA-encoded library is a collection of small molecules covalently linked to DNA that has unique information about the identity and the structure of each library member. A DNA-encoded chemical library (DEL) is broadly adopted… read more here.
Keywords: dna; dna encoded; encoded libraries; dels review ... See more keywords
DNA-encoded libraries via late-stage functionalization strategies: a review.
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DOI: 10.1039/d3cc01075a
Abstract: The hit finding strategy in drug discovery has undergone a tremendous change in the past decade with the advent of DNA-encoded libraries with diverse chemical libraries. The miniaturization of the assays has enabled high-throughput screening… read more here.
Keywords: dna; libraries via; late stage; encoded libraries ... See more keywords
Recent advances in DNA-encoded libraries.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc02904j
Abstract: The DNA-encoded library (DEL), a novel high-throughput screening platform that synergistically combines the strengths of combinatorial chemistry and genetic barcoding, has transitioned from a theoretical framework to a valuable technology within the pharmaceutical research landscape.… read more here.
Keywords: chemistry; advances dna; recent advances; encoded libraries ... See more keywords