Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.
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DOI: 10.1039/d0cc01474e
Abstract: We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible… read more here.
Keywords: phase synthesis; dna encoded; solid phase; synthesis dna ... See more keywords
DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output
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DOI: 10.1039/d0ra09889b
Abstract: A DNA-encoded library is a collection of small molecules covalently linked to DNA that has unique information about the identity and the structure of each library member. A DNA-encoded chemical library (DEL) is broadly adopted… read more here.
Keywords: dna; dna encoded; encoded libraries; dels review ... See more keywords
DNA-encoded libraries via late-stage functionalization strategies: a review.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01075a
Abstract: The hit finding strategy in drug discovery has undergone a tremendous change in the past decade with the advent of DNA-encoded libraries with diverse chemical libraries. The miniaturization of the assays has enabled high-throughput screening… read more here.
Keywords: dna; libraries via; late stage; encoded libraries ... See more keywords