Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer
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DOI: 10.3389/fgene.2022.970619
Abstract: Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP1, SPATA5, MFF, TSPOAP1, PHB2,… read more here.
Keywords: intergenic sequences; encoded mitochondrial; breast cancer; coding regions ... See more keywords
The Role of Nuclear-Encoded Mitochondrial tRNA Charging Enzymes in Human Inherited Disease
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DOI: 10.3390/genes13122319
Abstract: Aminoacyl-tRNA synthetases (ARSs) are highly conserved essential enzymes that charge tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear-encoded human ARS genes, 17 encode enzymes are exclusively targeted to the… read more here.
Keywords: encoded mitochondrial; ars genes; disease; nuclear encoded ... See more keywords