Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity
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DOI: 10.1002/advs.202417205
Abstract: CD47 inhibitors have emerged as promising candidates in cancer immunotherapy by activating macrophage phagocytosis through CD47/SIRPĪ± signal blockade and enhancing dendritic cell antigen presentation. However, their clinical efficacy remains limited and is accompanied by severe… read more here.
Keywords: antitumor; inhibitor; encoding cd47; localized delivery ... See more keywords