Intratumoral gene transfer of mRNAs encoding interleukin-12 in combination with decoy-resistant interleukin-18 improves local and systemic antitumor immunity.
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DOI: 10.1158/2326-6066.cir-22-0373
Abstract: Interleukin-12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding interleukin-12 (IL-12)… read more here.
Keywords: encoding interleukin; antitumor; decoy; intratumoral gene ... See more keywords