Mutations in the MRPS28 gene encoding the small mitoribosomal subunit protein bS1m in a patient with intrauterine growth retardation, craniofacial dysmorphism and multisystemic involvement
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DOI: 10.1093/hmg/ddy441
Abstract: Mitochondria contain a dedicated translation system, which is responsible for the intramitochondrial synthesis of 13 mitochondrial DNA (mtDNA)-encoded polypeptides essential for the biogenesis of oxidative phosphorylation (OXPHOS) complexes I and III-V. Mutations in nuclear genes… read more here.
Keywords: protein; gene encoding; small mitoribosomal; encoding small ... See more keywords
Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis
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DOI: 10.1126/science.adf1354
Abstract: Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide-based encoding is hampered by inherent limitations of information stability and density. In this… read more here.
Keywords: information; small molecule; encoding small; synthesis ... See more keywords