Early Invasive or Conservative Strategies for Older Patients With Acute Coronary Syndromes: A Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2025.2058
Abstract: Importance The optimal management strategy for older patients who present with acute coronary syndrome (ACS) remains unclear due to a paucity of randomized evidence. New large and longer-term randomized data are available. Objective To test… read more here.
Keywords: end; invasive conservative; invasive strategy; older patients ... See more keywords
Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non–Small Cell Lung or Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.17547
Abstract: Key Points Question What surrogate end point for capturing worsening disease is most correlated with overall survival (OS) in large linked clinicogenomic data sets? Findings In this cohort study of patients with non–small cell lung… read more here.
Keywords: overall survival; end; patients non; non small ... See more keywords
Assessment of Surrogate End Point Trends in Clinical Trials to Approve Oncology Drugs From 2001 to 2020 in Japan
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.8875
Abstract: Key Points Question How often are surrogate end points used to support the approval of anticancer drugs, and are confirmatory studies that use overall survival as an end point conducted in Japan? Findings In this… read more here.
Keywords: oncology; end point; surrogate end; end points ... See more keywords
Overall Survival and Quality-of-Life Superiority in Modern Phase 3 Oncology Trials: A Meta-Epidemiological Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2025.1002
Abstract: Importance Alternative end points, such as progression-free survival, are increasingly used in phase 3 randomized clinical trials (RCTs). However, alternative end points are often not valid surrogates for overall survival and quality of life (QOL)… read more here.
Keywords: oncology; end; qol; superiority ... See more keywords
Ten-Year Outcomes of Off-Pump vs On-Pump Coronary Artery Bypass Grafting in the Department of Veterans Affairs: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA surgery"
DOI: 10.1001/jamasurg.2021.7578
Abstract: Importance The long-term benefits of off-pump ("beating heart") vs on-pump coronary artery bypass grafting (CABG) remain controversial. Objective To evaluate the 10-year outcomes and costs of off-pump vs on-pump CABG in the Department of Veterans… read more here.
Keywords: year; pump; pump group; end ... See more keywords
Placebo Control and Blinding in Randomized Trials of Procedural Interventions: A Systematic Review and Meta-Regression.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA surgery"
DOI: 10.1001/jamasurg.2024.0718
Abstract: Importance Unlike medications, procedural interventions are rarely trialed against placebo prior to becoming accepted in clinical practice. When placebo-controlled trials are eventually conducted, procedural interventions may be less effective than previously believed. Objective To investigate… read more here.
Keywords: end; end points; procedural interventions; placebo ... See more keywords
Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13041
Abstract: Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis. The utilization of cfDNA fragmentomics for… read more here.
Keywords: end; cfdna; size; end motifs ... See more keywords
Retrieval of Compositional End‐Members From Mars Exploration Rover Opportunity Observations in a Soil‐Filled Fracture in Marathon Valley, Endeavour Crater Rim
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Geophysical Research"
DOI: 10.1002/2017je005339
Abstract: The Opportunity rover investigated a gentle swale on the rim of Endeavour crater called Marathon Valley where a series of bright planar outcrops are cut into polygons by fractures. A wheel scuff performed on one… read more here.
Keywords: end members; endeavour crater; marathon valley; end ... See more keywords
A daily end‐to‐end quality assurance workflow for MR‐guided online adaptive radiation therapy on MR‐Linac
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12786
Abstract: Abstract Purpose Magnetic Resonance (MR)‐guided online adaptive radiation therapy (MRgOART), enabled with MR‐Linac, has potential to revolutionize radiation therapy. MRgOART is a complex process. This work is to introduce a comprehensive end‐to‐end quality assurance (QA)… read more here.
Keywords: radiation therapy; end; workflow; online adaptive ... See more keywords
End‐to‐end unsupervised cycle‐consistent fully convolutional network for 3D pelvic CT‐MR deformable registration
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12968
Abstract: Abstract Objective To improve the efficiency of computed tomography (CT)‐magnetic resonance (MR) deformable image registration while ensuring the registration accuracy. Methods Two fully convolutional networks (FCNs) for generating spatial deformable grids were proposed using the… read more here.
Keywords: image; end; method; cycle consistent ... See more keywords
Giant Photo‐Magneto‐Thermoelectric Effect of End‐On Oriented PEDOT Grown from Self‐Assembled 3D Tectons
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202105297
Abstract: Conductive polymers (CPs) are arranged in the end‐on direction on graphene surfaces using 3D tectons of ZnPc assemblies, to control carrier transport from hot to cold via external magnetic fields. Poly(3,4‐ethylenedioxythiophene)s doped with tosylate are… read more here.
Keywords: magneto thermoelectric; film; end; end oriented ... See more keywords