G-quadruplex structural transition driven by a platinum compound
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac572
Abstract: Abstract G-quadruplex (G4) transitions play integral roles in regulating biological functions and can be modified by ligands. However, little is known about G4 transitions. Herein, we reveal distinct pathways of a platinum(II) compound Pt-phen converting… read more here.
Keywords: phen; quadruplex structural; end binding; platinum compound ... See more keywords
The dimeric organization that enhances the microtubule end-binding affinity of EB1 is susceptible to phosphorylation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.241216
Abstract: Microtubules dynamics is regulated by the plus end-tracking proteins (+TIPs) in cells. End binding protein 1 (EB1) acts as a master regulator in +TIPs networks by targeting microtubule growing ends and recruiting other factors. However,… read more here.
Keywords: end binding; dimeric organization; eb1; binding affinity ... See more keywords
Role of tau N-terminal motif in the secretion of human tau by End Binding proteins
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0210864
Abstract: For unknown reasons, humans appear to be particular susceptible to developing tau pathology leading to neurodegeneration. Transgenic mice are still undoubtedly the most popular and extensively used animal models for studying Alzheimer's disease and other… read more here.
Keywords: end binding; motif; tau; binding proteins ... See more keywords