Utility of Circulating Free DNA Fragmentomics in the Prediction of Pathological Response after Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.
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DOI: 10.1093/clinchem/hvac173
Abstract: BACKGROUND A "Watch and Wait" (W&W) approach has become an alternative to surgery for locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). Precise prediction of pathological complete response (pCR) will improve patient selection for… read more here.
Keywords: locally advanced; dna; end motif; response ... See more keywords
Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis.
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DOI: 10.1093/clinchem/hvac197
Abstract: BACKGROUND Nuclear-derived cell-free DNA (cfDNA) molecules in blood plasma are nonrandomly fragmented, bearing a wealth of information related to tissues of origin. DNASE1L3 (deoxyribonuclease 1 like 3) is an important player in shaping the fragmentation… read more here.
Keywords: microbial cfdna; cfdna; microbial dna; end motif ... See more keywords