Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer
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DOI: 10.1001/jamanetworkopen.2019.18939
Abstract: This systematic review and meta-analysis evaluates whether progression-free survival is a validated surrogate end point for overall survival in patients with advanced ovarian cancer. read more here.
Keywords: end point; free survival; point overall; surrogate end ... See more keywords
Incidence of Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials
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DOI: 10.1001/jamanetworkopen.2023.13819
Abstract: This cross-sectional study assesses the frequency of reporting of primary end point changes among active oncology phase 3 randomized clinical trials. read more here.
Keywords: among active; end point; point changes; primary end ... See more keywords
Assessment of Surrogate End Point Trends in Clinical Trials to Approve Oncology Drugs From 2001 to 2020 in Japan
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DOI: 10.1001/jamanetworkopen.2023.8875
Abstract: Key Points Question How often are surrogate end points used to support the approval of anticancer drugs, and are confirmatory studies that use overall survival as an end point conducted in Japan? Findings In this… read more here.
Keywords: oncology; end point; surrogate end; end points ... See more keywords
Progression‐free survival at 2 years post‐autologous transplant: a surrogate end point for overall survival in follicular lymphoma
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DOI: 10.1002/cam4.1217
Abstract: Overall survival (OS) is the gold‐standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course. We analyzed the validity… read more here.
Keywords: end; end point; overall survival; progression free ... See more keywords
The validity of progression‐free survival 2 as a surrogate trial end point for overall survival
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DOI: 10.1002/cncr.34085
Abstract: Overall survival (OS) is the gold‐standard end point for oncology trials. However, the availability of multiple therapeutic options after progression and crossover to receive investigational agents confound and delay OS data maturation. Progression‐free survival 2… read more here.
Keywords: free survival; end point; progression free; survival ... See more keywords
Persistence of the solution to the Euler equations in an end‐point critical Triebel–Lizorkin space
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DOI: 10.1002/mma.10443
Abstract: Local stay of the solutions to the Euler equations for an ideal incompressible fluid in the end‐point Triebel–Lizorkin space F1,∞sℝd$$ {F}_{1,\infty}^s\left({\mathbb{R}}^d\right) $$ with s≥d+1$$ s\ge d+1 $$ is clarified. read more here.
Keywords: triebel lizorkin; lizorkin space; euler equations; end point ... See more keywords
End‐Point Prediction of Converter Steelmaking Based on Main Process Data
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DOI: 10.1002/srin.202400151
Abstract: In this article, main process data, notably time–series data such as lance position patterns, are analyzed during converter steelmaking, and methodologies in data processing and transforming are proposed. In this study, utilizing both the transformed… read more here.
Keywords: converter steelmaking; end point; point; process data ... See more keywords
Effect of high‐dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)
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DOI: 10.1016/j.ahj.2017.09.002
Abstract: Importance In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high‐dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with… read more here.
Keywords: tact; high dose; end point; dose oral ... See more keywords
Age and composite end-point events in medium follow-up of patients with carotid artery total occlusion using drug therapy.
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DOI: 10.1016/j.atherosclerosis.2017.09.006
Abstract: BACKGROUND AND AIMS The outcome of carotid artery total occlusion (CATO) is unclear. The aim of this study is to report the medium incidence of composite end-point events and risk factors (especially age), in patients… read more here.
Keywords: point events; age; composite end; end point ... See more keywords
Validation of the Incremental Shuttle Walk Test as a Clinical End Point in Bronchiectasis
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DOI: 10.1016/j.chest.2018.09.019
Abstract: BACKGROUND: A validated clinical end point is needed to assess response to therapies in bronchiectasis. OBJECTIVES: The goal of this study was to assess the reliability, validity, and responsiveness of the incremental shuttle walk test… read more here.
Keywords: clinical end; bronchiectasis; end; end point ... See more keywords
Outcome of pitavastatin versus atorvastatin therapy in patients with hypercholesterolemia at high risk for atherosclerotic cardiovascular disease.
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DOI: 10.1016/j.ijcard.2020.01.006
Abstract: BACKGROUND There has been no report about outcome of pitavastatin versus atorvastatin therapy in high-risk patients with hypercholesterolemia. METHODS Hypercholesterolemic patients with one or more risk factors for atherosclerotic diseases (n = 664, age = 65, male = 54%, diabetes = 76%, primary… read more here.
Keywords: therapy; risk; end point; pitavastatin ... See more keywords