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   Articles with "end processing" as a keyword



Birth of a poly(A) tail: Mechanisms and control of mRNA polyadenylation.

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recommendations! Published in 2022 at "FEBS open bio"

DOI: 10.1002/2211-5463.13528

Abstract: During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two-step 3'-end processing reaction in which the pre-mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail… read more here.

Keywords: poly tail; birth poly; polyadenylation; end processing ... See more keywords

The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3'-End Processing Following UV-Induced DNA Damage.

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recommendations! Published in 2017 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2016.11.033

Abstract: Pre-mRNA 3'-end processing, the process through which almost all eukaryotic mRNAs acquire a poly(A) tail is generally inhibited during the cellular DNA damage response leading to a profound impact on the level of protein expression… read more here.

Keywords: mrna end; dna damage; end processing; pre mrna ... See more keywords

Molecular Insights into the Substrate-Assisted Mechanism of Viral DNA 3′-End Processing in Intasome of Prototype Foamy Virus Integrase from Molecular Dynamic and QM/MM Studies

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recommendations! Published in 2019 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.9b00276

Abstract: Integrases participates in two important steps for virus replication such as 3'-end processing of viral DNA ( vDNA) and nuclear entry of host DNA ( hDNA). In this work insight into the structural changes in… read more here.

Keywords: substrate assisted; mechanism; end processing;

The functionality of telomerase depends on CPF–CF induced 3′end processing of its RNA component TLC1 and a novel Nrd1–Nab3 surveillance mechanism

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf480

Abstract: Abstract Telomere elongation is driven by telomerase, which consists of several proteins and the ncRNA component TLC1 in yeast. While many ncRNAs are terminated via the Nrd1–Nab3–Sen1 (NNS) pathway, we found that TLC1 requires cleavage… read more here.

Keywords: nrd1 nab3; end processing; cpf; component tlc1 ... See more keywords
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Structural basis for mRNA 3′-end processing

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recommendations! Published in 2017 at "Science"

DOI: 10.1126/science.358.6366.1015-q

Abstract: Structural Biology The eukaryotic mRNA 3′-end processing machinery interacts with the transcription machinery and adds the polyadenylation tail on the mRNA substrate. Casanal et al. used cryo-electron microscopy, mass spectrometry, and biochemical reconstitutions to show… read more here.

Keywords: mrna end; structural basis; end processing; end ... See more keywords

UBE3D Regulates mRNA 3′-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells

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recommendations! Published in 2022 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00174-22

Abstract: We have previously described the role of an essential Saccharomyces cerevisiae gene, important for cleavage and polyadenylation 1 (IPA1), in the regulation of gene expression through its interaction with Ysh1, the endonuclease subunit of the… read more here.

Keywords: mrna end; regulation; end; end processing ... See more keywords
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3'-End Processing of Eukaryotic mRNA: Machinery, Regulation, and Impact on Gene Expression.

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recommendations! Published in 2023 at "Annual review of biochemistry"

DOI: 10.1146/annurev-biochem-052521-012445

Abstract: Formation of the 3' end of eukaryotic mRNAs is a key step in the production of a mature transcript. This process is mediated by a number of protein factors that cleave the pre-mRNA, add a… read more here.

Keywords: mrna; end; end processing; biochemistry ... See more keywords

The S. pombe mitochondrial transcriptome.

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recommendations! Published in 2018 at "RNA"

DOI: 10.1261/rna.064477.117

Abstract: Mitochondrial gene expression is largely controlled through post-transcriptional processes including mitochondrial RNA (mt-RNA) processing, modification, decay, and quality control. Defective mitochondrial gene expression results in mitochondrial oxidative phosphorylation (OXPHOS) deficiency and has been implicated in… read more here.

Keywords: processing; end processing; rna; pombe mitochondrial ... See more keywords

Modulation of mRNA 3′-End Processing and Transcription Termination in Virus-Infected Cells

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.828665

Abstract: Eukaryotic mRNA 3´-end processing is a multi-step process beginning with pre-mRNA transcript cleavage followed by poly(A) tail addition. Closely coupled to transcription termination, 3´-end processing is a critical step in the regulation of gene expression,… read more here.

Keywords: transcription termination; mrna end; end; end processing ... See more keywords