Birth of a poly(A) tail: Mechanisms and control of mRNA polyadenylation.
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DOI: 10.1002/2211-5463.13528
Abstract: During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two-step 3'-end processing reaction in which the pre-mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail… read more here.
Keywords: poly tail; birth poly; polyadenylation; end processing ... See more keywords
The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3'-End Processing Following UV-Induced DNA Damage.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2016.11.033
Abstract: Pre-mRNA 3'-end processing, the process through which almost all eukaryotic mRNAs acquire a poly(A) tail is generally inhibited during the cellular DNA damage response leading to a profound impact on the level of protein expression… read more here.
Keywords: mrna end; dna damage; end processing; pre mrna ... See more keywords
Molecular Insights into the Substrate-Assisted Mechanism of Viral DNA 3′-End Processing in Intasome of Prototype Foamy Virus Integrase from Molecular Dynamic and QM/MM Studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00276
Abstract: Integrases participates in two important steps for virus replication such as 3'-end processing of viral DNA ( vDNA) and nuclear entry of host DNA ( hDNA). In this work insight into the structural changes in… read more here.
Keywords: substrate assisted; mechanism; end processing;
Structural basis for mRNA 3′-end processing
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.358.6366.1015-q
Abstract: Structural Biology The eukaryotic mRNA 3′-end processing machinery interacts with the transcription machinery and adds the polyadenylation tail on the mRNA substrate. Casanal et al. used cryo-electron microscopy, mass spectrometry, and biochemical reconstitutions to show… read more here.
Keywords: mrna end; structural basis; end processing; end ... See more keywords
UBE3D Regulates mRNA 3′-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00174-22
Abstract: We have previously described the role of an essential Saccharomyces cerevisiae gene, important for cleavage and polyadenylation 1 (IPA1), in the regulation of gene expression through its interaction with Ysh1, the endonuclease subunit of the… read more here.
Keywords: mrna end; regulation; end; end processing ... See more keywords
3'-End Processing of Eukaryotic mRNA: Machinery, Regulation, and Impact on Gene Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-052521-012445
Abstract: Formation of the 3' end of eukaryotic mRNAs is a key step in the production of a mature transcript. This process is mediated by a number of protein factors that cleave the pre-mRNA, add a… read more here.
Keywords: mrna; end; end processing; biochemistry ... See more keywords
The S. pombe mitochondrial transcriptome.
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DOI: 10.1261/rna.064477.117
Abstract: Mitochondrial gene expression is largely controlled through post-transcriptional processes including mitochondrial RNA (mt-RNA) processing, modification, decay, and quality control. Defective mitochondrial gene expression results in mitochondrial oxidative phosphorylation (OXPHOS) deficiency and has been implicated in… read more here.
Keywords: processing; end processing; rna; pombe mitochondrial ... See more keywords
Modulation of mRNA 3′-End Processing and Transcription Termination in Virus-Infected Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.828665
Abstract: Eukaryotic mRNA 3´-end processing is a multi-step process beginning with pre-mRNA transcript cleavage followed by poly(A) tail addition. Closely coupled to transcription termination, 3´-end processing is a critical step in the regulation of gene expression,… read more here.
Keywords: transcription termination; mrna end; end; end processing ... See more keywords