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   Articles with "end resection" as a keyword



CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination

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recommendations! Published in 2025 at "European Journal of Immunology"

DOI: 10.1002/eji.202451585

Abstract: Downstream of 53BP1‐RIF1 lies the Shieldin (SHLD) protein complex, which comprises MAD2L2/REV7, SHLD3, SHLD2, and SHLD1, and the CTC1‐STN1‐TEN1 (CST) complex. During immunoglobulin heavy‐chain (Igh) class switch recombination (CSR), 53BP1‐RIF1‐SHLD promotes productive end‐joining by limiting… read more here.

Keywords: igh class; class switch; end resection; class ... See more keywords

Bacterial colonization in the apical part of extracted human teeth following root-end resection and filling: a confocal laser scanning microscopy study

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recommendations! Published in 2017 at "Clinical Oral Investigations"

DOI: 10.1007/s00784-017-2107-1

Abstract: ObjectivesThe purpose of this study was to evaluate Enterococcus faecalis colonization at the apical part of root canals following root-end resection and filling using confocal laser scanning microscopy (CLSM).Materials and methodsThe apical 3-mm root-ends of… read more here.

Keywords: resection filling; microscopy; end resection; following root ... See more keywords

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.08.008

Abstract: DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières… read more here.

Keywords: end resection; dna end; repair; samhd1 ... See more keywords

Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining.

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recommendations! Published in 2017 at "DNA repair"

DOI: 10.1016/j.dnarep.2017.03.002

Abstract: The primary pathways for DNA double strand break (DSB) repair are homologous recombination (HR) and non-homologous end-joining (NHEJ). The choice between HR and NHEJ is influenced by the extent of DNA end resection, as extensive… read more here.

Keywords: end joining; end resection; end; dna end ... See more keywords

ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1

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recommendations! Published in 2021 at "Cell Death Discovery"

DOI: 10.1038/s41420-021-00633-7

Abstract: To maintain genomic stability, the mammalian cells has evolved a coordinated response to DNA damage, including activation of DNA repair and cell cycle checkpoint processes. Exonuclease 1 (EXO1)-dependent excision of DNA ends is important for… read more here.

Keywords: zgrf1; dna; end resection; homologous recombination ... See more keywords

Regulatory control of DNA end resection by Sae2 phosphorylation

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06417-5

Abstract: DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods,… read more here.

Keywords: sae2; end resection; end; dna end ... See more keywords

Chk2 homologue Mek1 limits Exo1-dependent DNA end resection during meiotic recombination in S. cerevisiae.

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recommendations! Published in 2024 at "Genetics"

DOI: 10.1093/genetics/iyae112

Abstract: The conserved Rad2/XPG family 5'-3' exonuclease, Exonuclease 1 (Exo1), plays many roles in DNA metabolism including during resolution of DNA double strand breaks (DSBs) via homologous recombination. Prior studies provided evidence that the end-resection activity… read more here.

Keywords: chk2 homologue; recombination; resection; end resection ... See more keywords

Homologous recombination suppresses transgenerational DNA end resection and chromosomal instability in fission yeast

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad160

Abstract: Abstract Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying mechanism remains unclear. Using… read more here.

Keywords: end resection; fission yeast; end; chromosomal instability ... See more keywords

MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.

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recommendations! Published in 2023 at "Nucleic acids research"

DOI: 10.1093/nar/gkad308

Abstract: DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied.… read more here.

Keywords: end resection; msh2 msh3; resection; end ... See more keywords

Abstract 2920: ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in Ovarian cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-2920

Abstract: DNA double strand breaks (DSB) results in the accumulation of abnormal nucleic fragments in the cytosol, which activates nucleic acid sensors such as cGAS, DHX9, and AIM2, leading to innate immune responses. Intriguingly, these sensors… read more here.

Keywords: cancer; ovarian cancer; end resection; zbp1 ... See more keywords

An in vitro study of a novel intraoperative 3D-printed device for intentional replantation.

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recommendations! Published in 2025 at "BMC oral health"

DOI: 10.1186/s12903-025-07422-z

Abstract: To improve the accuracy and efficiency of intentional replantation, we designed a novel intraoperative three-dimensionally printed device. This study aimed to evaluate its assistance in intentional replantation by comparing the accuracy and efficiency of the… read more here.

Keywords: device; end resection; intentional replantation; root end ... See more keywords