Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes
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DOI: 10.1038/leu.2017.122
Abstract: Autologous stem cell transplantation (ASCT) is a standard treatment for eligible multiple myeloma (MM) patients, but many patients will relapse after ASCT and require subsequent therapy. The proteasome inhibitor carfilzomib is approved for relapsed or… read more here.
Keywords: endeavor; carfilzomib based; multiple myeloma; stem cell ... See more keywords
Efficacy and safety profile of deep responders to carfilzomib-based therapy: a subgroup analysis from ASPIRE and ENDEAVOR
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DOI: 10.1038/s41375-020-01049-5
Abstract: To understand the profile of best responders (complete response or better [≥CR]) to carfilzomib, we described the characteristics, progression-free survival (PFS), overall survival (OS) data, and the safety of patients who achieved ≥CR to carfilzomib-based… read more here.
Keywords: endeavor; treatment; carfilzomib based; aspire endeavor ... See more keywords
Reconstructing Retirement as an Enterprising Endeavor
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DOI: 10.1177/1056492618818773
Abstract: This article explores issues of age and enterprise in later life as manifested in tensions between retiree and entrepreneurial identities. We utilize the concept of a discursive event to examine time-bound online data, specifically media… read more here.
Keywords: retirement; retirement enterprising; endeavor; reconstructing retirement ... See more keywords
Carfilzomib and dexamethasone (Kd56) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (RRMM): Updated overall survival (OS), safety, and subgroup analysis of ENDEAVOR.
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DOI: 10.1200/jco.2018.36.15_suppl.8032
Abstract: 8032Background: The phase 3 ENDEAVOR trial demonstrated significantly improved PFS and OS with Kd56 vs Vd in RRMM patients (pts; Dimopoulos Lancet Oncol 2016 and 2017). We report updated data after... read more here.
Keywords: endeavor; carfilzomib dexamethasone; dexamethasone kd56; dexamethasone ... See more keywords
Exogenous Cannabinoids Impair Effort-Related Decision-Making via Affecting Neural Synchronization between the Anterior Cingulate Cortex and Nucleus Accumbens
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DOI: 10.3390/brainsci13030413
Abstract: Humans and animals frequently make an endeavor-based choice based on assessing reinforcement value and response costs. The cortical-limbic-striatal pathway mediates endeavor-based choice behavior, including the nucleus accumbens (NAc) and the anterior cingulate cortex (ACC). Furthermore,… read more here.
Keywords: endeavor; related decision; decision making; decision ... See more keywords