βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12638
Abstract: Endothelial–mesenchymal transition (EndMT) has emerged as an essential bioprocess responsible for the development of organ fibrosis. We have previously reported that fibroblast growth factor receptor 1 (FGFR1) is involved in the anti‐EndMT effect of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline… read more here.
Keywords: klb; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords
Exercise Induced Endothelial Mesenchymal Transition (EndMT) Facilitates Meniscal Fibrocartilage Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403788
Abstract: The meniscus is a semilunar wedge‐shaped fibrocartilage tissue within the knee joint that is important for withstanding mechanical shock during joint motion. The intrinsic healing capacity of meniscus tissue is very limited, which makes meniscectomy… read more here.
Keywords: mesenchymal transition; fibrocartilage; meniscus; endmt ... See more keywords
Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cardiovascular medicine"
DOI: 10.1016/j.tcm.2017.03.008
Abstract: The inner lumen of the blood vessels is covered by a thin layer of cells, known as endothelial cells. The integrity of endothelial cells is important for the development of the cardiovascular system and for… read more here.
Keywords: medicine; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords
Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac190
Abstract: AIMS Endothelial-to-mesenchymal transition (EndMT) is a fundamental process in vascular remodeling. However, the precise regulatory mechanism of vascular remodeling during neointima formation and source of neointima cells are not entirely understood. METHODS AND RESULTS To… read more here.
Keywords: endmt; cell; mesenchymal transition; endothelial mesenchymal ... See more keywords
TRPV4 channels mediate TGF-β2-induced endothelial-to-mesenchymal transition (EndMT) via Rho/Snail mechanotransduction pathway
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1136
Abstract: Endothelial-to-mesenchymal transition (EndMT) is a critical cellular differentiation process implicated in embryonic development and cardiovascular diseases including atherosclerosis and cardiac fibrosis. Although soluble factors such as TGF-β are major mediators of EndMT, mechanical forces such… read more here.
Keywords: physiology; endmt; trpv4; tgf induced ... See more keywords
Abstract 4122717: An Epigenetic Drug, GSK126 Mitigates Endothelial to Mesenchymal Transition Attenuating Atherosclerosis in Diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4122717
Abstract: Background: Endothelial to mesenchymal transition (EndMT) involves transformation of an endothelial to mesenchymal like cellular state. Recent studies implicate EndMT in atherosclerosis development. Diabetes is associated with both EndMT as well as accelerated atherosclerosis. Experimental… read more here.
Keywords: mesenchymal transition; gsk 126; atherosclerosis; endmt ... See more keywords
Endothelial-to-Mesenchymal Transition.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.119.314813
Abstract: EndMT is an intricate cellular differentiation process whereby endothelial cells detach and migrate away from the endothelium and, to varying extents, decrease endothelial properties and acquire mesenchymal features. First described in developing heart valves as… read more here.
Keywords: heart; endmt; valve endothelial; endothelial cells ... See more keywords
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320694
Abstract: Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a critical driver of vascular inflammation and atherosclerosis, and TGF-β (transforming growth factor β) is a key mediator of EndMT. Both EndMT and atherosclerosis are promoted by… read more here.
Keywords: endmt; endmt atherosclerosis; flow; tgf ... See more keywords
Paeonol Attenuates the Endothelial-to-Mesenchymal Transition Induced by TGF-β1 in Human Umbilical Vein Endothelial Cells through ALK5-Smad2/3 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Current neurovascular research"
DOI: 10.2174/1567202620666230202124037
Abstract: Background： Paeonol (Pae)， the main active compound of the root of Paeonia albiflora, is efficacious in treating atherosclerosis (AS). Endothelial dysfunction is throughout the pathological progression of AS. It is expected that inhibition of Endothelial-to-mesenchymal… read more here.
Keywords: endmt; mesenchymal transition; endothelial cells; pae ... See more keywords
Role of endothelial cells in vascular calcification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.895005
Abstract: Vascular calcification (VC) is active and regulates extraosseous ossification progress, which is an independent predictor of cardiovascular disease (CVD) morbidity and mortality. Endothelial cells (ECs) line the innermost layer of blood vessels and directly respond… read more here.
Keywords: endothelial cells; role endothelial; vascular calcification; endmt ... See more keywords
A Computational Model of the Endothelial to Mesenchymal Transition
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00040
Abstract: Endothelial cells (ECs) form the lining of lymph and blood vessels. Changes in tissue requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they may differentiate into mesenchymal cells (MCs).… read more here.
Keywords: mesenchymal transition; endmt; endothelial mesenchymal; model ... See more keywords