Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152742
Abstract: Abstract Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization of O-and N-propargylated compounds is described. The reaction is promoted by potassium tert-butoxide and allows a fast access to interesting heterocycles which were easily… read more here.
Keywords: phosphonoheterocycles via; synthesis phosphonoheterocycles; cyclization; via base ... See more keywords
Total Synthesis of Resiniferatoxin Enabled by Radical-Mediated Three-Component Coupling and 7-endo Cyclization.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10177
Abstract: Resiniferatoxin (1) belongs to a daphnane diterpenoid family and has strong agonistic effects on TRPV1, a transducer of noxious temperature and chemical stimuli. The densely oxygenated trans-fused 5/7/6-tricarbocycle (ABC-ring) of 1 presents a daunting challenge… read more here.
Keywords: endo cyclization; synthesis resiniferatoxin; synthesis; total synthesis ... See more keywords
endo-Cyclization of unsaturated RO2 radicals from the gas-phase ozonolysis of cyclohexadienes.
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DOI: 10.1039/c7cc01350g
Abstract: Unsaturated RO2 radicals from the ozonolysis of cyclodienes can readily undergo an endo-cyclization step under atmospheric conditions forming a new ring-containing RO2 radical after further O2 addition. This path represents an extension of the atmospheric… read more here.
Keywords: unsaturated ro2; cyclization unsaturated; endo cyclization; ro2 radicals ... See more keywords
Selective 7-endo-Cyclization of 3-Aza-5-alkenols through Oxidative Pd(II)-Catalyzed Olefin Oxyarylation
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DOI: 10.1055/s-0036-1590939
Abstract: 3-Aza-5-alkenols undergo selective 7-endo-trig cyclization when treated with a catalytic Pd(II) species, CuCl2 and ArSnBu3 giving 7-aryl-substituted oxazepanes. The intramolecular alkoxylation occurs with formation of a seven-membered ring only when associated with an arylating step.… read more here.
Keywords: endo cyclization; aza alkenols; selective endo;