Self-assembly of a disulfide-containing core/shell nanocomplex with intracellular environment-sensitive facilitated endo-lysosomal escape for enhanced antitumor efficacy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-05515-4
Abstract: A receptor-mediated, active-targeting and glutathione (GSH) turn-on charge-reversal core/shell nanocomplex HA-MEA-s-s-TGA/PAMAM@DOX was constructed to achieve increased stability, improved cellular uptake, facilitated endo-lysosomal escape and enhanced antitumor efficacy. This nanocomplex was composed of anionic hyaluronic acid… read more here.
Keywords: lysosomal escape; facilitated endo; dox; shell ... See more keywords
Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
Sign Up to like & getrecommendations! Published in 2020 at "Cell Calcium"
DOI: 10.1016/j.ceca.2020.102212
Abstract: Abstract The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are… read more here.
Keywords: could endo; ion channel; sars cov2; channel achilles ... See more keywords
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.09.005
Abstract: Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia… read more here.
Keywords: endo lysosomal; dysfunction; neurodegenerative diseases; lysosomal dysfunction ... See more keywords
Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.016
Abstract: Several lines of evidence have shown that defects in the endo-lysosomal autophagy degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's Disease (AD) pathogenesis and pathophysiology. Early pathological changes, such as marked enlargement… read more here.
Keywords: disease; pathogenesis; proteasome system; endo lysosomal ... See more keywords
Metal-Organic Framework-Based Nanoplatform for Intracellular Environment-Responsive Endo/Lysosomal Escape and Enhanced Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b11972
Abstract: Nowadays, efficient endo/lysosomal escape and the subsequent release of drugs into the cytosol are the major obstacles for nanoplatform-based cancer therapy. Herein, we first report a metal-organic framework-based nanoplatform (doxorubicin@ZIF-8@AS1411) for intracellular environment-responsive endo/lysosomal escape… read more here.
Keywords: cancer; endo lysosomal; cancer therapy; lysosomal escape ... See more keywords
Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68248-z
Abstract: Enzymatic degradation of protein antigens by endo-lysosomal proteases in antigen-presenting cells is crucial for achieving cellular immunity. Structural changes caused by vaccine production process steps, such as formaldehyde inactivation, could affect the sensitivity of the… read more here.
Keywords: proteolytic degradation; degradation; treatment; cathepsin ... See more keywords
HSPA5 Promotes Attachment and Internalization of Porcine Epidemic Diarrhea Virus through Interaction with the Spike Protein and the Endo-/Lysosomal Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00549-23
Abstract: PEDV infection causes severe piglet mortality and threatens the global pig industry. However, the complex invasion mechanism of PEDV makes its prevention and control difficult. ABSTRACT Porcine epidemic diarrhea virus (PEDV) has caused huge economic… read more here.
Keywords: internalization; lysosomal pathway; infection; hspa5 ... See more keywords
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-019-0134-9
Abstract: BackgroundBrain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals across the brain capillary endothelium involves… read more here.
Keywords: system; lysosomal system; brain endothelial; endothelial cells ... See more keywords
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Brain"
DOI: 10.1186/s13041-019-0504-x
Abstract: Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes… read more here.
Keywords: autophagic endo; disease; lysosomal dysfunction; clearance ... See more keywords
Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s376380
Abstract: Abstract Mood disorders are disabling conditions that cause significant functional impairment. Due to the clinical heterogeneity and complex nature of these disorders, diagnostic and treatment strategies face challenges. The etiology of mood disorders is multifactorial,… read more here.
Keywords: system; endo lysosomal; lysosomal autophagy; autophagy pathway ... See more keywords
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosomal System in Human Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00118
Abstract: The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal structures (EELSs) is one of the… read more here.
Keywords: cog; defects cog; golgi trafficking; golgi ... See more keywords