Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines.
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DOI: 10.1021/acs.orglett.8b01240
Abstract: A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6- endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good… read more here.
Keywords: copper promoted; trig cyclization; promoted endo; endo trig ... See more keywords
Synthesis of tetrahydrochromenes and dihydronaphthofurans via a cascade process of [3 + 3] and [3 + 2] annulation reactions: mechanistic insight for 6-endo-trig and 5-exo-trig cyclisation
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DOI: 10.1039/d2ra08163f
Abstract: Substituted tetrahydrochromenes and dihydronaphthofurans are easily accessible by the treatment of β-tetralone with trans-β-nitro styrene derived Morita–Baylis–Hillman (MBH) acetates through a formal [3 + 3]/[3 + 2] annulation. The reaction proceeds through a cascade Michael/oxa-Michael… read more here.
Keywords: exo trig; tetrahydrochromenes dihydronaphthofurans; annulation; trig ... See more keywords
Rh(II)-Catalyzed Synthesis of 1,3-Diols via 5- endo - trig Cyclization of Silyl Radicals
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DOI: 10.1055/a-2600-0327
Abstract: 1,3-Diols, which are a frequent motif in biologically active molecules, can be prepared from readily available allylic alcohols via formal anti-Markovnikov hydration. The commonly employed hydroboration–oxidation sequence for the synthesis of terminal alcohols is challenging… read more here.
Keywords: trig cyclization; silyl radicals; endo trig; trig ... See more keywords