Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL‐α, induces autism spectrum disorder‐like and co‐morbid phenotypes in adult C57BL/J mice
Sign Up to like & getrecommendations! Published in 2021 at "Autism Research"
DOI: 10.1002/aur.2520
Abstract: Accumulating evidence links dysfunction in the endocannabinoid system (ECS) with the pathology of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Variants in ECS genes CNR1 and DAGLA are associated with neurological phenotypes in humans. The… read more here.
Keywords: endocannabinoid; c57bl mice; enzyme dgl; spectrum disorder ... See more keywords
Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.01.001
Abstract: Graphical abstract Figure. No Caption available. Background and aims: Molecular basis of abdominal pain in IBD is not fully characterized. Serotonin (5‐HT) increases visceral pain severity and contributes to exacerbation of inflammation. Moreover, it is… read more here.
Keywords: endocannabinoid; serotonin; abdominal pain; colitis ... See more keywords
Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators
Sign Up to like & getrecommendations! Published in 2020 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.01.012
Abstract: The adolescent brain displays high vulnerability to the deleterious effects of ethanol, including greater risk of developing alcohol use disorder later in life. Here, we characterized the gene expression of the endocannabinoid system (ECS) and… read more here.
Keywords: etoh rats; endocannabinoid; hippocampus; ethanol ... See more keywords
The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118109
Abstract: Rheumatoid arthritis is an inflammatory autoimmune disease, characterized by synovial proliferation, destruction to articular cartilage and severe pain. The cannabinoids obtained from Cannabis sativa exhibited their actions via cannabinoid-1 and -2 receptors, which also provides… read more here.
Keywords: endocannabinoid signaling; endocannabinoid system; endocannabinoid; rheumatoid arthritis ... See more keywords
The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174419000813
Abstract: Abstract The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2… read more here.
Keywords: endocannabinoid; linoleic acid; mrna expression; linoleic ... See more keywords
Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior
Sign Up to like & getrecommendations! Published in 2020 at "Molecular psychiatry"
DOI: 10.1038/s41380-020-00905-1
Abstract: Enhancing endocannabinoid signaling produces anxiolytic- and antidepressant-like effects, but the neural circuits involved remain poorly understood. The medial habenula (MHb) is a phylogenetically-conserved epithalamic structure that is a powerful modulator of anxiety- and depressive-like behavior.… read more here.
Keywords: endocannabinoid; anxiety depressive; endocannabinoid signaling; like behavior ... See more keywords
Endocannabinoid Receptor Expression in Early Zebrafish Development.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental neuroscience"
DOI: 10.1159/000522383
Abstract: The endocannabinoid system is widely studied due to its interactions with cannabis and its role in modulating physiological responses. While most research has focused on the effects of cannabis on adult endocannabinoid systems, recent studies… read more here.
Keywords: development; expression; receptor expression; first detected ... See more keywords
Old Strategies and New Perspectives in Modulating the Endocannabinoid System
Sign Up to like & getrecommendations! Published in 2019 at "Current Bioactive Compounds"
DOI: 10.2174/1573407214666180627144214
Abstract: Endocannabinoid System (ES) has gained over the years a leading position in scientific research thanks to its involvement in numerous patho/physiological conditions. Accordingly, its main components, such as receptors, enzymes and mediators, have become important… read more here.
Keywords: new perspectives; strategies new; endocannabinoid; endocannabinoid system ... See more keywords
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076509
Abstract: A significant body of evidence shows that neuroinflammation is one of the key processes in the development of brain pathology in trauma, neurodegenerative disorders, and epilepsy. Various brain insults, including severe and prolonged seizure activity… read more here.
Keywords: modulation endocannabinoid; status epilepticus; lithium pilocarpine; expression ... See more keywords