Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24172
Abstract: The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for investigations on the effects of cannabis‐based therapeutics in brain pathology. Ever since, a… read more here.
Keywords: signaling brain; relevance; brain; glial cells ... See more keywords
Endocannabinoid signaling in oligodendroglia
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DOI: 10.1002/glia.24180
Abstract: In the central nervous system, oligodendrocytes synthesize the myelin, a specialized membrane to wrap axons in a discontinuous way allowing a rapid saltatory nerve impulse conduction. Oligodendrocytes express a number of growth factors and neurotransmitters… read more here.
Keywords: signaling oligodendroglia; endocannabinoid signaling;
Endocannabinoid signaling in the central nervous system
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24280
Abstract: It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the… read more here.
Keywords: system; cell; signaling central; central nervous ... See more keywords
Therapeutic Cannabis and Endocannabinoid Signaling System Modulator Use in Otolaryngology Patients
Sign Up to like & getrecommendations! Published in 2018 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.154
Abstract: 1) review benefits and risks of cannabis use, with emphasis on otolaryngic disease processes; 2) define and review the endocannabinoid signaling system (ESS); and 3) review state and federal regulations for the use and research… read more here.
Keywords: signaling system; otolaryngology; endocannabinoid signaling; cannabis endocannabinoid ... See more keywords
Proteomics and Lipidomics in the Elucidation of Endocannabinoid Signaling in Healthy and Schizophrenia Brains
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DOI: 10.1002/pmic.201700270
Abstract: Interest in the modulation of endocannabinoid signaling has increased since the discovery of receptors for compounds of Cannabis sativa. Endocannabinoids are crucial neuromodulators of many brain functions and changes in the ligands and their receptors… read more here.
Keywords: schizophrenia; lipidomics elucidation; elucidation endocannabinoid; endocannabinoid signaling ... See more keywords
Brain endocannabinoid signaling exhibits remarkable complexity
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.06.012
Abstract: The endocannabinoid (eCB) signaling system is one of the most extensive of the mammalian brain. Despite the involvement of only few specific ligands and receptors, the system encompasses a vast diversity of triggered mechanisms and… read more here.
Keywords: brain endocannabinoid; signaling exhibits; system; endocannabinoid signaling ... See more keywords
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.078
Abstract: Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses… read more here.
Keywords: mediates local; signaling mediates; excitatory; endocannabinoid signaling ... See more keywords
Imaging the endocannabinoid signaling system
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2021.109451
Abstract: The endocannabinoid (eCB) system is one of the most widespread neuromodulatory systems in the mammalian brain, with a multifaceted role in functions ranging from development to synaptic plasticity. Endocannabinoids are synthesized on demand from membrane… read more here.
Keywords: ecb; system; endocannabinoid signaling; microscopy ... See more keywords
The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis.
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DOI: 10.1016/j.lfs.2020.118109
Abstract: Rheumatoid arthritis is an inflammatory autoimmune disease, characterized by synovial proliferation, destruction to articular cartilage and severe pain. The cannabinoids obtained from Cannabis sativa exhibited their actions via cannabinoid-1 and -2 receptors, which also provides… read more here.
Keywords: endocannabinoid signaling; endocannabinoid system; endocannabinoid; rheumatoid arthritis ... See more keywords
Endocannabinoid signaling impairs syncytialization: Using flow cytometry to evaluate forskolin-induced cell fusion.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.10.028
Abstract: Cytotrophoblast cells fuse to form the syncytiotrophoblast, the main structure responsible for the placenta's specialized functions. This complex process denominated syncytialization is fundamental for a correct pregnancy outcome. We observed that the endocannabinoid anandamide disrupts… read more here.
Keywords: cell; signaling impairs; endocannabinoid signaling; flow cytometry ... See more keywords
Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior
Sign Up to like & getrecommendations! Published in 2020 at "Molecular psychiatry"
DOI: 10.1038/s41380-020-00905-1
Abstract: Enhancing endocannabinoid signaling produces anxiolytic- and antidepressant-like effects, but the neural circuits involved remain poorly understood. The medial habenula (MHb) is a phylogenetically-conserved epithalamic structure that is a powerful modulator of anxiety- and depressive-like behavior.… read more here.
Keywords: endocannabinoid; anxiety depressive; endocannabinoid signaling; like behavior ... See more keywords