Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Current Diabetes Reports"
DOI: 10.1007/s11892-017-0924-x
Abstract: Purpose of reviewThe purpose of the review was to revisit the possibility of the endocannabinoid system being a therapeutic target for the treatment of obesity by focusing on the peripheral roles in regulating appetite and… read more here.
Keywords: system; visiting endocannabinoid; endocannabinoid system; system therapeutic ... See more keywords
Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson’s and Alzheimer’s Diseases: a Review
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02054-6
Abstract: Neurodegeneration leading to Parkinson’s disease (PD) and Alzheimer’s disease (AD) has become a major health burden globally. Current treatments mainly target controlling symptoms and there are no therapeutics available in clinical practice to preventing the… read more here.
Keywords: current aspects; endocannabinoid system; neurodegeneration; system targeted ... See more keywords
Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02800-y
Abstract: The endocannabinoid system (ECS) is composed of the endocannabinoid ligands anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors (CB1 and CB2) and the enzymes involved in their synthesis and metabolism (N-acyltransferase and fatty acid… read more here.
Keywords: stress; inflammation nitro; nitro oxidative; oxidative stress ... See more keywords
Cannabinoid-Based Therapies and Brain Development: Potential Harmful Effect of Early Modulation of the Endocannabinoid System
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0550-4
Abstract: The endocannabinoid retrograde signaling pathway is widely expressed in the central nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and inhibitory) through long-term potentiation and long-term depression. The endocannabinoid system (ECS)… read more here.
Keywords: system; cbd; based therapies; endocannabinoid system ... See more keywords
The endocannabinoid system in mental disorders: Evidence from human brain studies
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.07.009
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Mental disorders have a high prevalence compared with many other health conditions and are the leading cause of disability worldwide. Several studies performed in the last years support… read more here.
Keywords: endocannabinoid system; brain studies; mental disorders; human brain ... See more keywords
Endocannabinoid mechanism in amphetamine-type stimulant use disorders: A short review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.08.042
Abstract: Recent evidence shows that the endocannabinoid system is involved in amphetamine-type stimulants (ATS) use disorders. To elucidate the role of the endocannabinoid system in ATS addiction, we reviewed results of studies using cannabinoid receptor agonists,… read more here.
Keywords: amphetamine type; system; endocannabinoid system; ats addiction ... See more keywords
The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118109
Abstract: Rheumatoid arthritis is an inflammatory autoimmune disease, characterized by synovial proliferation, destruction to articular cartilage and severe pain. The cannabinoids obtained from Cannabis sativa exhibited their actions via cannabinoid-1 and -2 receptors, which also provides… read more here.
Keywords: endocannabinoid signaling; endocannabinoid system; endocannabinoid; rheumatoid arthritis ... See more keywords
Effect of the Endocannabinoid System in Memory Updating and Forgetting
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DOI: 10.1016/j.neuroscience.2020.07.045
Abstract: Most memories of life experiences will be forgotten or modified over time. Although several studies have investigated the processes underlying memory formation, the mechanisms behind memory updating and forgetting remain unclear. The endocannabinoid system has… read more here.
Keywords: updating forgetting; endocannabinoid system; memory updating; memory ... See more keywords
Targeting Endocannabinoid System in Epilepsy: For Good or for Bad
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.12.013
Abstract: Epilepsy is a neurological disorder with a high prevalence worldwide. Several studies carried out during the last decades indicate that the administration of cannabinoids as well as the activation of the endocannabinoid system (ECS) represent… read more here.
Keywords: epilepsy good; system; good bad; system epilepsy ... See more keywords
Sex differences in the interactive effects of early life stress and the endocannabinoid system.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2020.106893
Abstract: Sex differences in both the endocannabinoid system and stress responses have been established for decades. While there is ample evidence that the sexes respond differently to stress and that the endocannabinoid system is involved in… read more here.
Keywords: system; exogenous cbs; endocannabinoid system; males females ... See more keywords
Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.02.029
Abstract: &NA; The association between chronic pain, depression and anxiety has gained particular attention due to high rates of comorbidity. Recent data demonstrated that the mesolimbic reward circuitry is involved in the pathology of chronic pain.… read more here.
Keywords: reward circuits; endocannabinoid system; dopamine signalling; signalling within ... See more keywords