The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12057
Abstract: Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS… read more here.
Keywords: bone protein; lung; metastasis; bone ... See more keywords
Regulation of extracellular matrix vesicles via rapid responses to steroid hormones during endochondral bone formation
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2017.12.003
Abstract: &NA; Endochondral bone formation is a precise and highly ordered process whose exact regulatory framework is still being elucidated. Multiple regulatory pathways are known to be involved. In some cases, regulation impacts gene expression, resulting… read more here.
Keywords: matrix vesicles; bone formation; extracellular matrix; matrix ... See more keywords
Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01848-1
Abstract: Endochondral bone formation is fundamental for skeletal development. During this process, chondrocytes undergo multiple steps of differentiation and coordinated transition from a proliferating to a hypertrophic stage, which is critical to advance skeletal development. Here,… read more here.
Keywords: bone formation; runx2; dmrt2; endochondral bone ... See more keywords
Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair
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DOI: 10.1177/0022034516668321
Abstract: The formation of the mandibular condylar cartilage (MCC) and its subchondral bone is an important but understudied topic in dental research. The current concept regarding endochondral bone formation postulates that most hypertrophic chondrocytes undergo programmed… read more here.
Keywords: bone formation; formation; bone; fracture repair ... See more keywords
C-type Natriuretic Peptide–induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac005
Abstract: Abstract Longitudinal bone growth is achieved by a tightly controlled process termed endochondral bone formation. C-type natriuretic peptide (CNP) stimulates endochondral bone formation through binding to its specific receptor, guanylyl cyclase (GC)-B. However, CNP/GC-B signaling… read more here.
Keywords: bone formation; activation; growth; bone ... See more keywords