Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse‐Inspired Bionic Niche
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202504057
Abstract: Various biomaterials have been developed to address challenging critical‐sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral ossification (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the… read more here.
Keywords: programming microenvironment; niche; spatiotemporally programming; bionic niche ... See more keywords
Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205059
Abstract: Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers a potential treatment alternative for advanced osteoarthritis. However, to date, no significant progress is made in… read more here.
Keywords: regeneration; dual modulation; endochondral ossification; humeral head ... See more keywords
Spheroid culture for chondrocytes triggers the initial stage of endochondral ossification
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28203
Abstract: Endochondral ossification is the process of bone formation derived from growing cartilage duringskeletal development. In previous studies, we provoked the osteocyte differentiation of osteoblast precursor cells under a three‐dimensional (3D) culture model. To recapitulate the… read more here.
Keywords: culture; stage endochondral; endochondral ossification; chondrocyte ... See more keywords
Sonographic evaluation of the endochondral ossification process of the thyroid cartilage in children
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Ultrasound"
DOI: 10.1002/jcu.22536
Abstract: To determine the sonographic appearances of the endochondral ossification process of the thyroid cartilage in children. read more here.
Keywords: process thyroid; endochondral ossification; thyroid cartilage; cartilage children ... See more keywords
Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-017-0824-9
Abstract: Bone fracture healing is achieved through the proliferation and differentiation of stem cells, while bone marrow stem cells (BMSCs) contribute to endochondral ossification. During fracture healing, mesenchymal progenitor cells first form a cartilaginous blastema that… read more here.
Keywords: bone; ossification mice; fracture healing; endochondral ossification ... See more keywords
Extracorporeal shock wave therapy accelerates endochondral ossification and fracture healing in a rat femur delayed-union model.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.084
Abstract: Extracorporeal shock wave therapy (ESWT) has been demonstrated to accelerate bone healing; however, the mechanism underlying ESWT-induced bone regeneration has not been fully elucidated. This study aimed to examine the effects of ESWT and the… read more here.
Keywords: fracture; ossification fracture; extracorporeal shock; endochondral ossification ... See more keywords
Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115042
Abstract: Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient activity of β-glucuronidase, leading to progressive accumulation of incompletely degraded heparan, dermatan, and chondroitin sulfate glycosaminoglycans (GAGs). Patients with MPS VII exhibit progressive skeletal… read more here.
Keywords: mucopolysaccharidosis; endochondral ossification; mps vii; ossification ... See more keywords
Prenatal nicotine exposure retards osteoclastogenesis and endochondral ossification in fetal long bones in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.07.005
Abstract: This study investigated the mechanisms underlying the retarded development of long bone in fetus by prenatal nicotine exposure (PNE) which had been demonstrated by our previous work. Nicotine (2.0 mg/kg.d) or saline was injected subcutaneously into… read more here.
Keywords: nicotine exposure; prenatal nicotine; endochondral ossification; ossification ... See more keywords
Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58122-9
Abstract: Endochondral ossification generates most of the load-bearing bones, recapitulating it in human cells remains a challenge. Here, we report generation of SOX9+ sclerotomal progenitors (scl-progenitors), a mesenchymal precursor at the pre-condensation stage, from human pluripotent… read more here.
Keywords: sox9 sclerotomal; sclerotomal progenitors; scl progenitors; ossification ... See more keywords
Effect of endoplasmic reticulum stress on bone and cartilage growth via endochondral ossification in broilers.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of animal science"
DOI: 10.1093/jas/skaf147
Abstract: Broilers in modern farming systems gain significant body weight, resulting in leg disorders in broilers. Long bones in the limbs extend after birth through endochondral ossification (EO), a process where bone replaces cartilage in pre-formed… read more here.
Keywords: stress; bone cartilage; cartilage; bone ... See more keywords
Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.21.497024
Abstract: Hutchinson-Gilford Progeria Syndrome results from a mutation in Lamin A, and it is characterized by the incorporation of progerin into the nuclear lamina. Progerin expression leads to alterations in genome architecture, nuclear morphology, and epigenetic… read more here.
Keywords: endochondral ossification; progeria syndrome; gilford progeria; hutchinson gilford ... See more keywords