Overcoming Endocrine Resistance in Breast Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.03.009
Abstract: Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype. Treatment of ER+ breast cancer comprises interventions that suppress estrogen production and/or target the ER directly (overall labeled as endocrine therapy). While endocrine… read more here.
Keywords: cancer; overcoming endocrine; endocrine resistance; breast cancer ... See more keywords
Tackling endocrine resistance in ER-positive HER2-negative advanced breast cancer: A tale of imprecision medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.04.002
Abstract: The selection of patients with advanced breast cancer as appropriate for endocrine manipulation according to hormone receptor status is a successful strategy. Unfortunately, the emergence of resistance is inevitable and subsequent treatment is not well… read more here.
Keywords: medicine; breast cancer; advanced breast; resistance ... See more keywords
Reversal of endocrine resistance via N6AMT1-NEDD4L pathway-mediated p110α degradation
Sign Up to like & getrecommendations! Published in 2024 at "Oncogene"
DOI: 10.1038/s41388-024-03238-3
Abstract: Approximately 70% of breast cancer (BC) cases are luminal-type (estrogen receptor-positive, ER+), suitable for endocrine therapy with tamoxifen as the most commonly used drug. However, about 30% of these patients develop tamoxifen resistance due to… read more here.
Keywords: breast cancer; resistance; degradation; endocrine resistance ... See more keywords
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01864-y
Abstract: Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, endocrine-resistant setting. No naturally occurring… read more here.
Keywords: breast cancer; resistance; naturally occurring; endocrine resistance ... See more keywords
ECM1 is associated with endocrine resistance in ER+ breast cancers
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2083235
Abstract: ABSTRACT Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER+) breast cancers has not been elucidated yet. We… read more here.
Keywords: breast; ecm1 associated; breast cancers; resistance breast ... See more keywords
DLL1-responsive PD-L1+ tumor-associated macrophages promote endocrine resistance in breast cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adr6207
Abstract: Estrogen receptor-positive (ER+) luminal breast cancer comprises 75% of patients with breast cancer and presents notable treatment challenges because of endocrine resistance. The effectiveness of immunotherapy in endocrine therapy-resistant luminal breast cancer remains unclear. This… read more here.
Keywords: cancer; tumor; breast cancer; endocrine resistance ... See more keywords
Abstract 6141: FGFR1 promotes endocrine resistance and regulates DNA sensing via STING modulation in hormone receptor-positive breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6141
Abstract: Alterations in the receptor tyrosine kinase Fibroblast Growth Factor Receptor 1 (FGFR1), such as gene amplification and overexpression, are frequently observed in hormone receptor-positive breast cancers, driving aberrant signaling pathways that promote tumor growth, metastasis,… read more here.
Keywords: receptor; cancer; breast; receptor positive ... See more keywords
Abstract S4-01: A novel BRD4 inhibitor enhances endocrine therapy efficacy and circumvents endocrine-resistance in estrogen receptor-positive breast cancer models
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-s4-01
Abstract: Background: The selective estrogen receptor (ER) down-regulator (SERD) fulvestrant (Ful) antagonizes ER activity and degrades ER protein in a dose-dependent manner in the preclinical and clinical settings, though its efficacy is limited by an incomplete… read more here.
Keywords: cell; breast cancer; efficacy; growth ... See more keywords
Abstract PO2-27-04: Unravelling the role of FGFR1 in innate immune sensing and endocrine resistance in breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po2-27-04
Abstract: Fibroblast Growth Factor Receptor 1 (FGFR1) has emerged as a critical player in various cancer types, including breast cancer. FGFR1 alterations, including gene amplification, overexpression, and activating mutations, have been identified in subsets of breast… read more here.
Keywords: cancer; breast cancer; breast; fgfr1 ... See more keywords
Abstract P2-03-17: Targeting NR2F2 overcomes multiple forms of endocrine resistance
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p2-03-17
Abstract: Endocrine resistance is frequently encountered in the clinic through a variety of mechanisms such as NF1 loss that induce alternative survival pathways and suppress estrogen responsiveness. While targeting the induced pathways such as the RAS-MAPK… read more here.
Keywords: cancer; resistance; targeting nr2f2; nf1 loss ... See more keywords
Genistein induces endocrine resistance in human breast cancer by suppressing H3K27 trimethylation.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0191
Abstract: Genistein (GE), the most important phytoestrogen in diet, is known to behave as a partial agonist of estrogen receptor α, and shows a proliferative effect on the growth of breast cancer cell lines. Recent research… read more here.
Keywords: long term; breast; term; cancer ... See more keywords