Overcoming Endocrine Resistance in Breast Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.03.009
Abstract: Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype. Treatment of ER+ breast cancer comprises interventions that suppress estrogen production and/or target the ER directly (overall labeled as endocrine therapy). While endocrine… read more here.
Keywords: cancer; overcoming endocrine; endocrine resistance; breast cancer ... See more keywords
Tackling endocrine resistance in ER-positive HER2-negative advanced breast cancer: A tale of imprecision medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.04.002
Abstract: The selection of patients with advanced breast cancer as appropriate for endocrine manipulation according to hormone receptor status is a successful strategy. Unfortunately, the emergence of resistance is inevitable and subsequent treatment is not well… read more here.
Keywords: medicine; breast cancer; advanced breast; resistance ... See more keywords
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01864-y
Abstract: Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, endocrine-resistant setting. No naturally occurring… read more here.
Keywords: breast cancer; resistance; naturally occurring; endocrine resistance ... See more keywords
ECM1 is associated with endocrine resistance in ER+ breast cancers
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2083235
Abstract: ABSTRACT Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER+) breast cancers has not been elucidated yet. We… read more here.
Keywords: breast; ecm1 associated; breast cancers; resistance breast ... See more keywords
Abstract S4-01: A novel BRD4 inhibitor enhances endocrine therapy efficacy and circumvents endocrine-resistance in estrogen receptor-positive breast cancer models
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-s4-01
Abstract: Background: The selective estrogen receptor (ER) down-regulator (SERD) fulvestrant (Ful) antagonizes ER activity and degrades ER protein in a dose-dependent manner in the preclinical and clinical settings, though its efficacy is limited by an incomplete… read more here.
Keywords: cell; breast cancer; efficacy; growth ... See more keywords
Genistein induces endocrine resistance in human breast cancer by suppressing H3K27 trimethylation.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0191
Abstract: Genistein (GE), the most important phytoestrogen in diet, is known to behave as a partial agonist of estrogen receptor α, and shows a proliferative effect on the growth of breast cancer cell lines. Recent research… read more here.
Keywords: long term; breast; term; cancer ... See more keywords
Dysregulation of TLR2 Serves as a Prognostic Biomarker in Breast Cancer and Predicts Resistance to Endocrine Therapy in the Luminal B Subtype
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00547
Abstract: Background: Breast cancer (BCa) is a serious global health burden among females, and the development of resistance represents an important challenge to BCa treatment. Here, we examined the expression of toll-like receptor 2 (TLR2) in… read more here.
Keywords: endocrine therapy; bca; tlr2; resistance ... See more keywords
ESR1 Methylation Measured in Cell-Free DNA to Evaluate Endocrine Resistance in Metastatic Breast Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105631
Abstract: ESR1 methylation was proposed as mechanism for endocrine resistance in metastatic breast cancer patients. To evaluate its potential as a minimally invasive biomarker, we investigated the feasibility of measuring ESR1 methylation in cell-free DNA (cfDNA)… read more here.
Keywords: methylation; resistance metastatic; esr1 methylation; endocrine resistance ... See more keywords