Evaluation of Alisertib Alone or Combined With Fulvestrant in Patients With Endocrine-Resistant Advanced Breast Cancer: The Phase 2 TBCRC041 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7949
Abstract: Importance Aurora A kinase (AURKA) activation, related in part to AURKA amplification and variants, is associated with downregulation of estrogen receptor (ER) α expression, endocrine resistance, and implicated in cyclin-dependent kinase 4/6 inhibitor (CDK 4/6i)… read more here.
Keywords: arm; endocrine resistant; breast cancer; randomized clinical ... See more keywords
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.008
Abstract: We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 tumors previously exposed to hormonal therapy, we identified an increased number of… read more here.
Keywords: breast cancers; genomic landscape; endocrine resistant; landscape endocrine ... See more keywords
Huaier extract restrains the proliferative potential of endocrine-resistant breast cancer cells through increased ATM by suppressing miR-203
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07550-9
Abstract: Endocrine therapy is one of the main treatments for breast cancer patients in the early stages. Tamoxifen and fulvestrant are the major drugs of endocrine therapy for breast cancer patients. However, acquired drug resistance often… read more here.
Keywords: huaier extract; endocrine resistant; breast cancer;
Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-2961
Abstract: Purpose: Endocrine resistance remains a major clinical challenge in estrogen receptor (ER)–positive breast cancer. Despite the encouraging results from clinical trials for the drugs targeting known survival signaling, relapse is still inevitable. There is an… read more here.
Keywords: kinase; endocrine resistant; resistant breast; breast cancer ... See more keywords
Abstract 4414: Targeting CCL5 signaling pathway in endocrine resistant breast cancer therapy
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4414
Abstract: Estrogen receptor (ER) is the primary transcription factor driving ∼75% of all breast cancers and serves as the target for endocrine therapies. However, resistance to endocrine therapy remains a critical clinical challenge, particularly in metastatic… read more here.
Keywords: cancer; breast cancer; ccl5; resistant breast ... See more keywords
Abstract P3-04-16: Steroid receptor co-activator 1 mediation of cancer cell reprogramming in endocrine resistant breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p3-04-16
Abstract: Cancer cells undergo dynamic and frequently reversible modifications and this cellular plasticity permits reprogramming in response to long term endocrine treatment. A well-established theory, the cancer stem cell theory; suggests that within an ER positive… read more here.
Keywords: endocrine resistant; breast cancer; cancer; endocrine ... See more keywords
Abstract P6-04-16: Glucocorticoid receptor signaling elicits anti-cancer effects in endocrine resistant breast cancer via induction of AZGP1
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p6-04-16
Abstract: Despite the availability of effective drugs that target ERα-positive breast cancer, ERα-positive disease still accounts for more breast cancer related deaths than any other subtype. Relapse in these patients is largely due to the development… read more here.
Keywords: azgp1; endocrine resistant; cancer; resistant breast ... See more keywords
Abstract PO3-16-04: Distribution of intrinsic subtypes in endocrine-resistant and endocrine-sensitive breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po3-16-04
Abstract: Background Breast cancer (BC) is a heterogeneous disease that can be divided into intrinsic molecular subtypes. Among the four intrinsic subtypes, Luminal A and Luminal B are the most common and associated with the best… read more here.
Keywords: cancer; distribution; intrinsic subtypes; her2 ... See more keywords
Transcriptomic profiles of endocrine-resistant breast cancer
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DOI: 10.1186/s12885-025-14826-1
Abstract: The majority of breast cancer patients have tumors expressing estrogen receptor α (ER) and are treated with adjuvant endocrine therapy. However, nearly one-third relapse, most with retained ER expression. This study investigated patients with ER-positive… read more here.
Keywords: cancer; breast cancer; endocrine resistant; gene sets ... See more keywords
S100β as a serum marker in endocrine resistant breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medicine"
DOI: 10.1186/s12916-017-0836-2
Abstract: BackgroundEndocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and inhibition of its signaling network… read more here.
Keywords: s100; endocrine; endocrine resistant; breast cancer ... See more keywords
8516 Role of ER, PR, IRS-1 Transcriptional Complexes in Endocrine Resistant Luminal Breast Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1824
Abstract: Abstract Disclosure: S. Schmidt: None. C.A. Lange: Consulting Fee; Self; Consultant for Astrin. In the United States, 1 in 8 women will develop invasive BC within their lifetime. For Luminal breast cancer expressing steroid hormone… read more here.
Keywords: cancer; breast cancer; breast; insulin ... See more keywords