The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-019-09536-6
Abstract: The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone produced in the gastrointestinal tract in response to nutrients. GIP has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic… read more here.
Keywords: gipr axis; gipr; endocrine tumors; gip gipr ... See more keywords
Zebrafish model of KRAS-initiated pancreatic endocrine tumor
Sign Up to like & getrecommendations! Published in 2019 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2019.1610058
Abstract: ABSTRACT Pancreatic cancer constitutes a genetic disease in which somatic mutations in the KRAS proto-oncogene are detected in 95% of cases. Activation of the KRAS proto-oncogene represents an initiating event in pancreatic tumorigenesis. Here, we… read more here.
Keywords: endocrine tumors; zebrafish model; endocrine; pancreatic endocrine ... See more keywords
Bone tissue and mineral metabolism in hereditary endocrine tumors: clinical manifestations and genetic bases
Sign Up to like & getrecommendations! Published in 2020 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-020-01380-1
Abstract: Inherited endocrine tumors are neoplasms of endocrine cells, transmitted via autosomal dominant germinal mutations. They present in two different forms: non-syndromic (patient has a single affected endocrine organ during his/her lifetime) or syndromic forms (multiple… read more here.
Keywords: metabolism; endocrine tumors; bone tissue; mineral metabolism ... See more keywords
DICER1 gene mutations in endocrine tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine-related cancer"
DOI: 10.1530/erc-17-0509
Abstract: In this review, the importance of the DICER1 gene in the function of endocrine cells is discussed. There is conclusive evidence that DICER1 mutations play a crucial role in the development, progression, cell proliferation, therapeutic… read more here.
Keywords: dicer1 gene; gene mutations; mutations endocrine; endocrine tumors ... See more keywords
65 YEARS OF THE DOUBLE HELIX: Classification of endocrine tumors in the age of integrated genomics.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine-related cancer"
DOI: 10.1530/erc-18-0116
Abstract: The classification of human cancers represents one of the cornerstones of modern pathology. Over the last century, surgical pathologists established the current taxonomy of neoplasia using traditional histopathological parameters, which include tumor architecture, cytological features… read more here.
Keywords: double helix; classification; endocrine tumors; classification endocrine ... See more keywords
Editorial: Stem Cells in Endocrine Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.722790
Abstract: 1 Department of Surgical Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy, 2 Institute for Diabetes and Cancer, Helmholtz Zentrum München, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HZ), Munich, Germany, 3 Department of Biology and Biotechnology "L.… read more here.
Keywords: endocrine tumors; university; department; cells endocrine ... See more keywords
Applications of spatially resolved omics in the field of endocrine tumors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.993081
Abstract: Endocrine tumors derive from endocrine cells with high heterogeneity in function, structure and embryology, and are characteristic of a marked diversity and tissue heterogeneity. There are still challenges in analyzing the molecular alternations within the… read more here.
Keywords: endocrine tumors; mass spectrometry; spatially resolved; endocrine ... See more keywords
The Vault Complex Is Significantly Involved in Therapeutic Responsiveness of Endocrine Tumors and Linked to Autophagy under Chemotherapeutic Conditions
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061783
Abstract: Simple Summary The vault complex, consisting of a major vault protein (MVP), two minor vault proteins (VPARP and TEP1), and small untranslated vault RNA molecules, is considered the largest intracellular ribonucleoprotein particle. Although in recent… read more here.
Keywords: therapeutic responsiveness; vault; endocrine tumors; vault complex ... See more keywords