Rapid Turnover of the Cardiac L-Type CaV1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.08.012
Abstract: Summary Calcium entry through CaV1.2 L-type calcium channels regulates cardiac contractility. Here, we study the impact of exocytic and post-endocytic trafficking on cell surface channel abundance in cardiomyocytes. Single-molecule localization and confocal microscopy reveal an… read more here.
Keywords: endocytic recycling; channel; cav1; surface availability ... See more keywords
Augmenting Intracellular Cargo Delivery of Extracellular Vesicles in Hypoxic Tissues through Inhibiting Hypoxia-Induced Endocytic Recycling.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c10351
Abstract: As mesenchymal stem-cell-derived small extracellular vesicles (MSC-sEVs) have been widely applied in treatment of degenerative diseases, it is essential to improve their cargo delivery efficiency in specific microenvironments of lesions. However, the interaction between the… read more here.
Keywords: msc sevs; endocytic recycling; hypoxia; delivery ... See more keywords
Corrigendum: Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42320
Abstract: Scientific Reports 6: Article number: 20727; published online: 17 February 2016; updated: 23 March 2017 A reader alerted us of a potential error in Figure 12B and its accompanying Supplementary Figure 13B, since the indicated… read more here.
Keywords: corrigendum endocytic; protein ehd1; endocytic recycling; recycling protein ... See more keywords
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2090667
Abstract: ABSTRACT ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms regulating KATP channel internalization… read more here.
Keywords: cardiac katp; katp; katp channel; katp channels ... See more keywords
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad023
Abstract: Abstract Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic tissues remains… read more here.
Keywords: fusion; lysosomal fusion; endocytic recycling; activity ... See more keywords
Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella‐containing vacuole
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Microbiology"
DOI: 10.1111/cmi.13151
Abstract: Legionella pneumophila requires the Dot/Icm translocation system to replicate in a vacuolar compartment within host cells. Strains lacking the translocated substrate SdhA form a permeable vacuole during residence in the host cell, exposing bacteria to… read more here.
Keywords: endocytic recycling; vacuole integrity; sdha mutant; sdha ... See more keywords
Accurate measurement of fast endocytic recycling kinetics in real time
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.231225
Abstract: ABSTRACT The fast turnover of membrane components through endocytosis and recycling allows precise control of the composition of the plasma membrane. Endocytic recycling can be rapid, with some molecules returning to the plasma membrane with… read more here.
Keywords: real time; endocytic recycling; fast endocytic; time ... See more keywords