Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202007880
Abstract: Macropinocytosis is a consequence of oncogenic alterations of cancer cells while most healthy cells are non‐macropinocytic. It is currently unclear whether macropinocytic cancer cells can be targeted rather than healthy cells, by adjusting the shape… read more here.
Keywords: cancer; shape; cancer cells; endocytosis ... See more keywords
Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000529
Abstract: Biohybrid nanosystems represent the cutting-edge research in biofunctionalization of micro- and nano-systems. Their physicochemical properties bring along advantages in the circulation time, camouflaging from the phagocytes, and novel antigens. This is partially a result of… read more here.
Keywords: endocytosis; cell; cell membrane; porous silicon ... See more keywords
Fe2+ Triggers Endocytosis of Carrier Proteins in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202502090
Abstract: Human serum albumin (HSA) plays an indispensable role as a carrier of endogenous and exogenous substances in vivo. The efficiency of endocytosis determines the transport capacity. However, the potential for enhancing the efficiency of HSA… read more here.
Keywords: transport; endocytosis; carrier; hsa endocytosis ... See more keywords
Lemon-Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105274
Abstract: Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, a biomimetic drug delivery system based on lemon-derived extracellular vesicles (EVs) nanodrugs (marked with heparin-cRGD-EVs-doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming cancer multidrug resistance.… read more here.
Keywords: cancer; energy; endocytosis; cancer multidrug ... See more keywords
Membrane Tension Regulation is Required for Wound Repair
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402317
Abstract: Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental, and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms… read more here.
Keywords: membrane tension; wound repair; membrane; endocytosis ... See more keywords
Enhancing Anti-Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202515472
Abstract: Engineered extracellular vesicles (EVs) represent a promising therapeutic strategy with many applications in cancer therapy. EVs derived from engineered tumor‐targeting killer cells, such as chimeric antigen receptor (CAR)‐T cells. However, the application of CAR‐T‐EVs is… read more here.
Keywords: extracellular vesicles; endocytosis; cd19; engineered extracellular ... See more keywords
Dynamin‐2 regulates microtubule stability via an endocytosis‐independent mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21723
Abstract: Microtubule stability and dynamics regulations are essential for vital cellular processes, such as microtubule‐dependent axonal transport. Dynamin is involved in many membrane fission events, such as clathrin‐mediated endocytosis. The ubiquitously expressed dynamin‐2 has been reported… read more here.
Keywords: endocytosis; dynamin; microtubule stability; heterozygous cells ... See more keywords
Leucine‐Rich Amelogenin Peptide (LRAP) Uptake by Cementoblast Requires Flotillin‐1 Mediated Endocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25453
Abstract: Basic, pre‐clinical, and clinical studies have documented the potential of amelogenin, and its variants, to affect cell response and tissue regeneration. However, the mechanisms are unclear. Thus, the aim of the present study was to… read more here.
Keywords: rich amelogenin; leucine rich; lrap uptake; endocytosis ... See more keywords
Intracellular transcytosis of albumin in glomerular endothelial cells after endocytosis through caveolae
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25817
Abstract: We previously described albumin endocytosis through caveolae in human renal glomerular endothelial cells (HRGECs). This suggested a new albumin transcytosis pathway, in addition to the fenestral pathway. As a next step, we investigated albumin transcytosis… read more here.
Keywords: caveolae; glomerular endothelial; endocytosis; endothelial cells ... See more keywords
CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31447
Abstract: Renal proximal tubular reabsorption of proteins and polypeptides is tightly regulated by a concerted action of the multi‐ligand receptors with subsequent processing from the clathrin‐coated pits to early/recycling and late endosomes and towards lysosomes. We… read more here.
Keywords: endocytosis; ccdc158; proximal tubular; tubular endocytosis ... See more keywords
Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12558
Abstract: Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by genetic defects in lysosomal enzymes or related factors. LSDs are associated with excessive accumulation of natural substrates in lysosomes leading to central nervous system and… read more here.
Keywords: snare; storage disorders; lysosomal storage; endocytosis ... See more keywords