Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202007880
Abstract: Macropinocytosis is a consequence of oncogenic alterations of cancer cells while most healthy cells are non‐macropinocytic. It is currently unclear whether macropinocytic cancer cells can be targeted rather than healthy cells, by adjusting the shape… read more here.
Keywords: cancer; shape; cancer cells; endocytosis ... See more keywords
Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000529
Abstract: Biohybrid nanosystems represent the cutting-edge research in biofunctionalization of micro- and nano-systems. Their physicochemical properties bring along advantages in the circulation time, camouflaging from the phagocytes, and novel antigens. This is partially a result of… read more here.
Keywords: endocytosis; cell; cell membrane; porous silicon ... See more keywords
Lemon-Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105274
Abstract: Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, a biomimetic drug delivery system based on lemon-derived extracellular vesicles (EVs) nanodrugs (marked with heparin-cRGD-EVs-doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming cancer multidrug resistance.… read more here.
Keywords: cancer; energy; endocytosis; cancer multidrug ... See more keywords
Dynamin‐2 regulates microtubule stability via an endocytosis‐independent mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21723
Abstract: Microtubule stability and dynamics regulations are essential for vital cellular processes, such as microtubule‐dependent axonal transport. Dynamin is involved in many membrane fission events, such as clathrin‐mediated endocytosis. The ubiquitously expressed dynamin‐2 has been reported… read more here.
Keywords: endocytosis; dynamin; microtubule stability; heterozygous cells ... See more keywords
Leucine‐Rich Amelogenin Peptide (LRAP) Uptake by Cementoblast Requires Flotillin‐1 Mediated Endocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25453
Abstract: Basic, pre‐clinical, and clinical studies have documented the potential of amelogenin, and its variants, to affect cell response and tissue regeneration. However, the mechanisms are unclear. Thus, the aim of the present study was to… read more here.
Keywords: rich amelogenin; leucine rich; lrap uptake; endocytosis ... See more keywords
Intracellular transcytosis of albumin in glomerular endothelial cells after endocytosis through caveolae
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25817
Abstract: We previously described albumin endocytosis through caveolae in human renal glomerular endothelial cells (HRGECs). This suggested a new albumin transcytosis pathway, in addition to the fenestral pathway. As a next step, we investigated albumin transcytosis… read more here.
Keywords: caveolae; glomerular endothelial; endocytosis; endothelial cells ... See more keywords
Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12558
Abstract: Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by genetic defects in lysosomal enzymes or related factors. LSDs are associated with excessive accumulation of natural substrates in lysosomes leading to central nervous system and… read more here.
Keywords: snare; storage disorders; lysosomal storage; endocytosis ... See more keywords
Synaptotagmin‐11 Is a novel hotspot in the pathogenesis of parkin‐linked Parkinson's disease: New implications for clinical targeting
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27369
Abstract: Of several identified loci, Syt-11, the encoding gene for synaptotagmin-11, is of the hottest PD risk genes. Syt-11 is a non-Ca-binding Syt and cause the inhibition of neural endocytosis and therefor vesicle recycling. Of note,… read more here.
Keywords: accumulation; wang colleagues; syt; endocytosis ... See more keywords
Measurements of Compensatory Endocytosis by Antibody Internalization and Quantification of Endocytic Vesicle Distribution in Adrenal Chromaffin Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1044-2_3
Abstract: Plasma membrane proteins are amenable to endocytosis assays since they are easily labeled by reagents applied in the extracellular medium. This has been widely exploited to study constitutive endocytosis or ligand-induced receptor endocytosis. Compensatory endocytosis… read more here.
Keywords: chromaffin cells; vesicle; antibody; endocytosis ... See more keywords
Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1070-2
Abstract: Objective and designNeutrophil generation of reactive oxygen species (ROS) is enhanced by exposure to pro-inflammatory agents in a process termed priming. Priming is depending on exocytosis of neutrophil granules and p47phox phosphorylation-dependent translocation of cytosolic… read more here.
Keywords: priming respiratory; endocytosis; human neutrophils; exocytosis ... See more keywords
The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03467-1
Abstract: Endocytosis of the amyloid precursor protein (APP) is critical for generation of β-amyloid, aggregating in Alzheimer's disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also termed… read more here.
Keywords: protein; rme; precursor protein; endocytosis ... See more keywords