Metabolic and epigenetic regulation of endoderm differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.09.002
Abstract: The endoderm, one of the three primary germ layers, gives rise to lung, liver, stomach, intestine, colon, pancreas, bladder, and thyroid. These endoderm-originated organs are subject to many life-threatening diseases. However, primary cells/tissues from endodermal… read more here.
Keywords: endoderm differentiation; regulation endoderm; metabolic epigenetic; differentiation ... See more keywords
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0572-2
Abstract: Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates. Here, we report that endoderm… read more here.
Keywords: protein; endoderm differentiation; brd3; differentiation ... See more keywords
Genome-scale screens identify JNK/JUN signaling as a barrier for pluripotency exit and endoderm differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0408-9
Abstract: Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highlighting the need for understanding developmental mechanisms. We… read more here.
Keywords: endoderm differentiation; genome scale; jnk jun; differentiation ... See more keywords
Pdx1 Is Transcriptionally Regulated by EGR-1 during Nitric Oxide-Induced Endoderm Differentiation of Mouse Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073920
Abstract: The transcription factor, early growth response-1 (EGR-1), is involved in the regulation of cell differentiation, proliferation, and apoptosis in response to different stimuli. EGR-1 is described to be involved in pancreatic endoderm differentiation, but the… read more here.
Keywords: differentiation; embryonic stem; nitric oxide; mouse embryonic ... See more keywords