Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis.
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DOI: 10.1016/j.biochi.2018.11.020
Abstract: Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused by alternative splicing… read more here.
Keywords: endonuclease; dnase; apoptosis; endog ... See more keywords
Meiotic viral attenuation through an ancestral apoptotic pathway
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DOI: 10.1073/pnas.1900751116
Abstract: Significance A hypothesis for the paradoxical evolution of programmed cell death posits that suicide mechanisms were co-opted from processes that were originally pro-survival. Here we show that meiotically programmed mitochondrial release of the Endonuclease G… read more here.
Keywords: viral attenuation; mitochondrial release; pathway; endog ... See more keywords
Apoptotic endonuclease EndoG inhibits telomerase activity and induces malignant transformation of human CD4+ T cells
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DOI: 10.1134/s0006297917010035
Abstract: Telomerase activity is regulated by an alternative splicing of mRNA of the telomerase catalytic subunit hTERT (human telomerase reverse transcriptase). Increased expression of the inactive spliced hTERT results in inhibition of telomerase activity. Little is… read more here.
Keywords: telomerase activity; telomerase; endog; cd4 cells ... See more keywords