Glucocorticoid receptor polymorphism BclI with increased glucocorticoid sensitivity has a positive influence on Quality of Life in Endogenous Cushing's syndrome in remission.
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DOI: 10.1093/ejendo/lvad043
Abstract: CONTEXT Patients with endogenous Cushing's syndrome (CS) may suffer from a wide range of neuropsychiatric symptoms leading to impaired quality of life (QoL). OBJECTIVE Glucocorticoid receptor (GR) polymorphisms are associated with increased (BclI and N363S)… read more here.
Keywords: sensitivity; glucocorticoid receptor; remission; cushing syndrome ... See more keywords
Co-Occurrence of Exogenous and Endogenous Cushing's Syndromes—Dilemma in Diagnosis
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DOI: 10.1155/2019/2986312
Abstract: Approach to patients who manifest with features of Cushing's syndrome often begin with exclusion of exposure to excessive exogenous source of glucocorticoids (GC). Most guidelines advocate no further assessment if excessive exogenous GC use is… read more here.
Keywords: cushing syndromes; occurrence exogenous; syndromes dilemma; cushing syndrome ... See more keywords
Circadian Plasma Cortisol Measurements Reflect Severity of Hypercortisolemia in Children with Different Etiologies of Endogenous Cushing Syndrome
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DOI: 10.1159/000464463
Abstract: Background: The utility of circadian cortisol variation in estimating the degree of hypercortisolemia in different forms of endogenous Cushing syndrome (CS) has not been evaluated in children yet. Methods: A retrospective cohort study, including children… read more here.
Keywords: cortisol; plasma cortisol; hypercortisolemia; cushing syndrome ... See more keywords
Levoketoconazole treatment in endogenous Cushing’s syndrome: extended evaluation of clinical, biochemical, and radiologic outcomes
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DOI: 10.1530/eje-22-0506
Abstract: Objective This extended evaluation (EE) of the SONICS study assessed the effects of levoketoconazole for an additional 6 months following open-label, 6-month maintenance treatment in endogenous Cushing’s syndrome. Design/Methods SONICS included dose-titration (150–600 mg BID),… read more here.
Keywords: extended evaluation; month; treatment endogenous; cushing syndrome ... See more keywords
Hypercoagulability and Risk of Venous Thromboembolic Events in Endogenous Cushing's Syndrome: A Systematic Meta-Analysis
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DOI: 10.3389/fendo.2018.00805
Abstract: Background: Hypercortisolism has been implicated in the development of venous thromboembolic events (VTE). We aimed to characterize VTE risk in endogenous Cushing's syndrome (CS) patients, compare that risk to other pathologies, and determine if there… read more here.
Keywords: thromboembolic events; vte; risk; cushing syndrome ... See more keywords