PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates
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DOI: 10.1016/j.isci.2020.101727
Abstract: Summary Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been deposited in the Protein Data Bank since 2001;… read more here.
Keywords: ppar; binding domain; ppar ligand; endogenous fatty ... See more keywords
Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion
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DOI: 10.2337/db17-1215
Abstract: The secretion of insulin from β-cells depends on extracellular factors, in particular glucose and other small molecules, some of which act on G-protein–coupled receptors. Fatty acids (FAs) have been discussed as exogenous secretagogues of insulin… read more here.
Keywords: secretion; endogenous fatty; insulin secretion; fatty acids ... See more keywords