Self-Assembly of Intelligent Nanoplatform for Endogenous H2S-Triggered Multimodal Cascade Therapy of Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01131
Abstract: The specific in situ generation and activation of therapeutic agents with high spatiotemporal precision is expected to revolutionize cancer treatment. Here, we develop an intelligent nanoplatform (termed as NP-Cu), which is constructed by assembling photosensitizer… read more here.
Keywords: cascade therapy; therapy; intelligent nanoplatform; endogenous h2s ... See more keywords
An Endogenous H2S-Activated Nanoplatform for Triple Synergistic Therapy of Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01346
Abstract: Overproduced hydrogen sulfide (H2S) is a highly potential target for precise colorectal cancer (CRC) therapy; herein, a novel 5-Fu/Cur-P@HMPB nanomedicine is developed by coencapsulation of the natural anticancer drug curcumin (Cur) and the clinical chemotherapeutic… read more here.
Keywords: synergistic therapy; therapy; triple synergistic; colorectal cancer ... See more keywords
Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc00118c
Abstract: The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the… read more here.
Keywords: gemcitabine; simultaneous fluorescence; fluorescence turn; endogenous h2s ... See more keywords
Evaluation of the Role of Toxicological Data in Discriminating Between H2S Femoral Blood Concentration Secondary to Lethal poisoning and Endogenous H2S Putrefactive Production
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.13291
Abstract: Hydrogen sulfide is a colorless gas and has a strong odor of rotten eggs. It is absorbed by the upper respiratory tract mucosa, and it causes histotoxic hypoxemia and respiratory depression by exerting an inhibitory… read more here.
Keywords: role toxicological; blood concentration; lethal poisoning; endogenous h2s ... See more keywords
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H2S in Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.1104
Abstract: Tissue ischemia and hypoxia caused by the abnormal proliferation of smooth muscle cells (SMCs) in the diabetic state is an important pathological basis for diabetic microangiopathy. Studies in recent years have shown that the chronic… read more here.
Keywords: muscle cells; proliferation; proliferation vascular; h2s ... See more keywords
Blocking Endogenous H2S Signaling Attenuated Radiation-Induced Long-Term Metastasis of Residual HepG2 Cells through Inhibition of EMT
Sign Up to like & getrecommendations! Published in 2018 at "Radiation Research"
DOI: 10.1667/rr15074.1
Abstract: Recurrence and metastasis of hepatocellular carcinoma (HCC) after radiotherapy are frequently observed in clinical practice. To date, the involved mechanism, endogenous hydrogen sulfide (H2S), has not been well understood and warrants investigation. Here we demonstrated… read more here.
Keywords: metastasis; h2s signaling; endogenous h2s; hepg2 ... See more keywords
Exogenous Hydrogen Sulfide Offers Neuroprotection on Intracerebral Hemorrhage Injury Through Modulating Endogenous H2S Metabolism in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00349
Abstract: Hydrogen sulfide (H2S), an important endogenous signaling molecule, has a significant neuroprotective role in the central nervous system. In this study, we examined the protective effects of exogenous H2S against intracerebral hemorrhage (ICH), as well… read more here.
Keywords: intracerebral hemorrhage; brain; endogenous h2s; hydrogen sulfide ... See more keywords
The Defensive Role of Endogenous H2S in Brassica rapa against Mercury-Selenium Combined Stress
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052854
Abstract: Plants are always exposed to the environment, polluted by multiple trace elements. Hydrogen sulfide (H2S), an endogenous gaseous transmitter in plant cells, can help plant combat single elements with excess concentration. Until now, little has… read more here.
Keywords: combined stress; mercury selenium; h2s; defensive role ... See more keywords
H2S in Horticultural Plants: Endogenous Detection by an Electrochemical Sensor, Emission by a Gas Detector, and Its Correlation with L-Cysteine Desulfhydrase (LCD) Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105648
Abstract: H2S has acquired great attention in plant research because it has signaling functions under physiological and stress conditions. However, the direct detection of endogenous H2S and its potential emission is still a challenge in higher… read more here.
Keywords: lcd; emission; gas detector; activity ... See more keywords
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134049
Abstract: Hydrogen sulfide (H2S), a gaseous signaling molecule, is associated with the development of various malignancies via modulating various cellular signaling cascades. Published research has established the fact that inhibition of endogenous H2S production or exposure… read more here.
Keywords: breast cancer; h2s; inhibition endogenous; endogenous h2s ... See more keywords