LAUSR

Impact of altered endogenous IgG on unspecific mAb clearance

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1 Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"

DOI: 10.1007/s10928-017-9524-2

Abstract: Immunodeficient mice are crucial models to evaluate the efficacy of monoclonal antibodies (mAbs). When studying mAb pharmacokinetics (PK), protection from elimination by binding to the neonatal Fc receptor (FcRn) is known to be a major… read more here.

Keywords: igg concentrations; endogenous igg; unspecific mab; mab clearance ... See more keywords