Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04291d
Abstract: Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion… read more here.
Keywords: aggregation; endogenous inhibition; inhibition iapp; iapp ... See more keywords
p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice
Sign Up to like & getrecommendations! Published in 2022 at "Neural Plasticity"
DOI: 10.1155/2022/3300327
Abstract: Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. The p38 MAPK pathway has attracted considerable attention in cerebral I/R injury (IRI),… read more here.
Keywords: mapk endogenous; p38; p38 mapk; endogenous inhibition ... See more keywords