Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.16023
Abstract: Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption of coordinated ENS activity can result in dysmotility. Pharmacological treatment options for dysmotility include targeting of G protein-coupled receptors (GPCRs) expressed by neurons… read more here.
Keywords: motility disorders; motility; endogenous ligand; allosteric modulators ... See more keywords
Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.606488
Abstract: While chronic kidney disease is prevalent in adults, obstructive nephropathy (ON) has been reported in both young and old patients. In ON, tubulointerstitial lesions (TILs) have been widely investigated, but glomerular lesions (GLs) have been… read more here.
Keywords: tlr8; endogenous ligand; collateral kidney; podocyte injury ... See more keywords
αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010582
Abstract: The opioid peptide β-endorphin coexists in the pituitary and brain in its αN-acetylated form, which does not bind to opioid receptors. We now report that these neuropeptides exhibited opposite effects in in vivo paradigms, in… read more here.
Keywords: acetyl endorphin; opioid receptor; endorphin endogenous; endogenous ligand ... See more keywords