The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects.
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DOI: 10.1016/j.dmpk.2020.11.003
Abstract: Cytochrome P450 (CYP) 3A-related drug-drug interaction (DDI) studies are needed during drug development to determine clinical interaction effects. We aimed to evaluate DDI between sildenafil and two CYP3A inhibitors, clarithromycin and itraconazole, regarding the changes… read more here.
Keywords: endogenous markers; cyp3a activity; drug; sildenafil ... See more keywords