Endogenous opioid system: a promising target for future smoking cessation medications
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4582-0
Abstract: BackgroundNicotine addiction continues to be a health challenge across the world. Despite several approved medications, smokers continue to relapse. Several human and animal studies have evaluated the role of the endogenous opioid system as a… read more here.
Keywords: cessation medications; endogenous opioid; opioid system; smoking cessation ... See more keywords
Endogenous opioid system in addiction and addiction-related behaviors
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2016.12.002
Abstract: Since the discovery and verification of the components of the endogenous opioid system in the 1970s, consisting of the mu, kappa, and delta-opioid receptors, and the cognate ligands β-endorphin, the enkephalins, and the dynorphins, a… read more here.
Keywords: addiction; addiction addiction; opioid system; system addiction ... See more keywords
Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.108025
Abstract: Historically, the roots of alcoholism have been linked to either environment or heredity. However, the interaction between these factors is still largely unexplored. The evidence supports a link between alcohol consumption and the endogenous opioid… read more here.
Keywords: expression rats; genes expression; opioid system; endogenous opioid ... See more keywords
Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0107-4
Abstract: Addiction has been proposed as a ‘reward deficient’ state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction.… read more here.
Keywords: endogenous opioid; opioid release; mor availability; following oral ... See more keywords
Endocannabinoid-Enhanced “Liking” in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals
Sign Up to like & getrecommendations! Published in 2018 at "Cannabis and Cannabinoid Research"
DOI: 10.1089/can.2018.0021
Abstract: Abstract Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial “hedonic hotspot” in nucleus accumbens (NAc) shell enhances hedonic impact, or “liking” reactions to sweet tastes. In this study, we probed within this… read more here.
Keywords: opioid signals; endogenous opioid; nucleus accumbens; hedonic hotspot ... See more keywords
Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abl5130
Abstract: Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin I to produce angiotensin II. In the brain, ACE is especially abundant in striatal tissue, but the function of ACE in striatal circuits remains poorly understood.… read more here.
Keywords: converting enzyme; brain; endogenous opioid; ace ... See more keywords
Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0804-y
Abstract: BackgroundThis study examined the development of chronic pain, a cardinal symptom of rheumatoid arthritis (RA), in mice with antigen- and collagen-induced arthritis (ACIA). Since the role of CD8+ T cells in arthritis is controversial, we… read more here.
Keywords: cd8; cd8 cells; inflammation; endogenous opioid ... See more keywords
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and β-Endorphin
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0087-21.2021
Abstract: Abstract Naltrexone is an opioid receptor antagonist approved for the treatment of alcohol and opioid use disorders at doses of 50–150 mg/d. Naltrexone has also been prescribed at much lower doses (3–6 mg/d) for the off-label treatment… read more here.
Keywords: endogenous opioid; opioid; pomc neurons; low dose ... See more keywords
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.958377
Abstract: Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also known… read more here.
Keywords: pathways kisspeptin; female reproduction; endogenous opioid; opioid peptides ... See more keywords
Episodic Ethanol Exposure in Adolescent Rats Causes Residual Alterations in Endogenous Opioid Peptides
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2018.00425
Abstract: Adolescent binge drinking is associated with an increased risk of substance use disorder, but how ethanol affects the central levels of endogenous opioid peptides is still not thoroughly investigated. The aim of this study was… read more here.
Keywords: ethanol exposure; exposure; endogenous opioid; ethanol ... See more keywords
The Involvement of the Endogenous Opioid System in the Gastrointestinal Aging in Mice and Humans
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073565
Abstract: Nearly 20% of elderly patients suffer from constipation, but the age-related changes in the gastrointestinal (GI) tract remain insufficiently elucidated. In this study, the alterations within the endogenous opioid system (EOS) as a potential cause… read more here.
Keywords: age; endogenous opioid; opioid system; dop ... See more keywords