HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1214-5
Abstract: BackgroundInterleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the vicious cycle of inflammation by inducing the expression of various other pro-inflammatory cytokines along with its own production.… read more here.
Keywords: endogenous production; production; activated microglia; nlrp3 inflammasome ... See more keywords
Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0267921
Abstract: Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial fluid viscosity,… read more here.
Keywords: endogenous production; hyaluronan prg4; cyclic loading; concentration ... See more keywords