The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60279-2
Abstract: Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin spreading… read more here.
Keywords: retroviral elements; kap1; endogenous retroviral; stem cells ... See more keywords
Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba8415
Abstract: Daxx loss causes coordinate dysregulation of ERVs and protein-coding genes after physiologic stress and impairs tissue recovery. Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in DAXX,… read more here.
Keywords: maintains endogenous; daxx; daxx maintains; silencing restricts ... See more keywords
Human Endogenous Retroviral Envelope Protein Syncytin-1 and Inflammatory Abnormalities in Neuropsychological Diseases
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DOI: 10.3389/fpsyt.2018.00422
Abstract: Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome. Recent studies have considered HERVs as potential pathogenic factors. The majority of HERV genes are mutated and not capable of encoding functional proteins; regardless,… read more here.
Keywords: inflammatory abnormalities; envelope; human endogenous; neuropsychological diseases ... See more keywords