Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26452
Abstract: Human endogenous retroviruses have been implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous retrovirus K (HERV‐K) subtype HML‐2 envelope (Env) in human neuronal cultures and in transgenic mice results in… read more here.
Keywords: lateral sclerosis; endogenous retrovirus; human endogenous; amyotrophic lateral ... See more keywords
A safety and pharmacodynamics study of temelimab, an antipathogenic human endogenous retrovirus type W envelope monoclonal antibody, in patients with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.1111/dom.14010
Abstract: To report the first study of temelimab, a monoclonal antibody neutralizing the pathogenic human endogenous retrovirus type W envelope, in patients with type 1 diabetes (T1D). read more here.
Keywords: type envelope; study temelimab; human endogenous; retrovirus type ... See more keywords
Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets
Sign Up to like & getrecommendations! Published in 2017 at "Xenotransplantation"
DOI: 10.1111/xen.12311
Abstract: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans. It has been… read more here.
Keywords: pig; retrovirus expression; characterization porcine; porcine endogenous ... See more keywords
SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-3523
Abstract: The identification of the SETDB1-mediated suppression of radiotherapy-induced viral mimicry reveals SETDB1 inhibition as a potential approach to sensitize tumors to radiotherapy by enhancing the type I interferon response. read more here.
Keywords: restrains endogenous; setdb1; setdb1 restrains; endogenous retrovirus ... See more keywords
Association of Human Endogenous Retrovirus-W (HERV-W) Copies with Pemphigus Vulgaris.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230418114152
Abstract: BACKGROUND Pemphigus is classified as a group of chronic, recurrent, and potentially fatal bullous autoimmune diseases that leads to blisters and skin lesions resulting from IgG antibodies and the loss of cellular connections in the… read more here.
Keywords: herv env; human endogenous; endogenous retrovirus; herv ... See more keywords
Variable Baseline Papio cynocephalus Endogenous Retrovirus (PcEV) Expression Is Upregulated in Acutely SIV-Infected Macaques and Correlated to STAT1 Expression in the Spleen
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00901
Abstract: Retroviral replication leaves a DNA copy in the host cell chromosome, which over millions of years of infection of germline cells has led to 5% of the human genome sequence being comprised of endogenous retroviruses… read more here.
Keywords: papio cynocephalus; pcev expression; expression; retrovirus pcev ... See more keywords
Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.797608
Abstract: Pig to human xenotransplantation is considered to be a possible approach to alleviate the shortage of human allografts. Porcine endogenous retrovirus (PERV) is the most significant pathogen in xenotransplantation. We screened for pigs that consistently… read more here.
Keywords: pol genes; porcine endogenous; non transmitting; endogenous retrovirus ... See more keywords
Related Endogenous Retrovirus-K Elements Harbor Distinct Protease Active Site Motifs
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01577
Abstract: Background: Endogenous retrovirus-K is a group of related genomic elements descending from retroviral infections in human ancestors. HML2 is the clade of these viruses which contains the most intact provirus copies. These elements can be… read more here.
Keywords: endogenous retrovirus; related endogenous; protease; active site ... See more keywords
Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12070726
Abstract: In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from… read more here.
Keywords: human endogenous; retrovirus cancer; cancer; endogenous retrovirus ... See more keywords