Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28350
Abstract: Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have… read more here.
Keywords: oncogenesis mechanisms; human endogenous; retroviruses cancer; cancer oncogenesis ... See more keywords
A new theory on autoimmunity with reference to multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Immunologic Research"
DOI: 10.1007/s12026-018-9003-x
Abstract: Recent genetic evidence points towards endogenous retroviruses as playing a pivotal role in the causation of multiple sclerosis and possibly other autoimmune diseases. We discuss various ways in which this association could be brought about.… read more here.
Keywords: sclerosis; new theory; endogenous retroviruses; multiple sclerosis ... See more keywords
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.05.020
Abstract: Summary The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the microbiota remain largely unknown. Here, we show that the skin microbiota… read more here.
Keywords: inflammatory responses; microbiota; promote homeostatic; retroviruses promote ... See more keywords
Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102068
Abstract: The Third International Workshop on Human Endogenous Retroviruses and disease (www.hervanddisease.com), addressing HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer, in Lyon, France on November 5-6th 2019, once again gathered… read more here.
Keywords: autoimmune chronic; elements autoimmune; human endogenous; endogenous retroviruses ... See more keywords
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.04.030
Abstract: The role of heterochromatin in cell fate specification during development is unclear. We demonstrate that loss of the lysine 9 of histone H3 (H3K9) methyltransferase G9a in the mammary epithelium results in de novo chromatin… read more here.
Keywords: stem cell; mammary gland; endogenous retroviruses; gland development ... See more keywords
Roles of Endogenous Retroviruses in Early Life Events.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.09.002
Abstract: A retrovirus that infected our ancestors 100 million years ago became a human gene that is expressed in embryos and cancers, and can be detected in the blood of pregnant women. Accumulating evidence suggests potential… read more here.
Keywords: retroviruses early; early life; endogenous retroviruses; roles endogenous ... See more keywords
Comment on: Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101040
Abstract: h R 1 In the short communication “Endogenous retroviruses expressed in uman tumours cannot be used as targets for anti-tumour vaccines ” 1] Joachim Denner argues that the idea we recently proposed [2] lacks cientific… read more here.
Keywords: used targets; tumours used; endogenous retroviruses; targets anti ... See more keywords
Discovery of endogenous retroviruses with mammalian envelopes in avian genomes uncovers long-term bird-mammal interaction.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.005
Abstract: Endogenous retroviruses (ERVs) arise from the infection and integration of past retroviruses into animal hosts. We performed large-scale genomic mining of 101 avian genomes for discovery of ERVs having none-avian origin and investigated the cross-species… read more here.
Keywords: avian genomes; retroviruses mammalian; discovery endogenous; group ... See more keywords
Unexpected low expression of porcine endogenous retroviruses (PERVs) in porcine expanded potential stem cells (EPSCs).
Sign Up to like & getrecommendations! Published in 2021 at "Virus research"
DOI: 10.1016/j.virusres.2021.198295
Abstract: Expanded potential stem cells (EPSCs) have been recently derived from porcine preimplantation embryos (Gao et al., 2019). These cells were shown to express key pluripotency genes, to be genetically stable and differentiate to derivatives of… read more here.
Keywords: perv; porcine; endogenous retroviruses; expression ... See more keywords
Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
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DOI: 10.1038/s41467-020-17206-4
Abstract: Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of transcriptional regulators are transposable elements (TEs), whose aberrant usage could… read more here.
Keywords: source enhancers; source; endogenous retroviruses; retroviruses source ... See more keywords
m6A RNA methylation regulates the fate of endogenous retroviruses.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-020-03135-1
Abstract: Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and… read more here.
Keywords: rna methylation; methylation; endogenous retroviruses; mettl3 mettl14 ... See more keywords