Perylene‐Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo‐Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204498
Abstract: Perylene derivatives can be stimulated by the hypoxic tumor microenvironment to generate radical anion that is proposed to arouse electron exchange with oxidizing substance, and in turn, realize reactive oxygen species (ROS) burst. Here, three… read more here.
Keywords: respiratory chain; perylene; ros burst; endogenous ros ... See more keywords
Rational Construction of Mitochondrial-targeting, Fluorescent Self-reporting Drug Delivery Platform for Combined Enhancement of Endogenous ROS Responsiveness.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c08336
Abstract: To maximize the utilization and response to the high oxidative stress environment of tumor sites while avoiding the dilemma of enhancing ROS response in a single way, Mitochondria-targeting combined with fluorescent self-reporting polymeric nanocarriers (1K-TPP… read more here.
Keywords: fluorescent self; self reporting; tpp tpp; endogenous ros ... See more keywords