Phenylephrine alleviates 131I damage in submandibular gland through promoting endogenous stem cell regeneration via lissencephaly-1 upregulation.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.114999
Abstract: Thyroid cancer is the most common endocrine malignancy. 131I ablation therapy is an effective treatment for patients with differentiated thyroid cancer (DTC) but frequently causes radiation damage in salivary glands (SGs). Stem cell-based regenerative therapy… read more here.
Keywords: cell regeneration; endogenous stem; stem cell; lis1 ... See more keywords
Re-education begins at home: an overview of the discovery of in vivo-active small molecule modulators of endogenous stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2018.1437140
Abstract: ABSTRACT Introduction: Degenerative diseases, such as Alzheimer’s disease, heart disease and arthritis cause great suffering and are major socioeconomic burdens. An attractive treatment approach is stem cell transplantation to regenerate damaged or destroyed tissues. However,… read more here.
Keywords: small molecules; endogenous stem; discovery; stem ... See more keywords