Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces
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DOI: 10.1038/s41467-024-54196-z
Abstract: The multifunctional proteins of class 2 CRISPR systems such as Cas9, have been employed to activate cryptic biosynthetic gene clusters (BGCs) in Streptomyces, which represent a large and hidden reservoir of natural products. However, such… read more here.
Keywords: endogenous type; natural product; type crispr; crispr ... See more keywords