Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.2820
Abstract: Importance As the worldwide burden of endometrial cancer continues to rise, interest is growing in the evaluation of early detection and prevention strategies among women at increased risk. Focusing efforts on women with postmenopausal bleeding… read more here.
Keywords: women pmb; cancer risk; endometrial cancer; postmenopausal bleeding ... See more keywords
Association of Mismatch Repair Mutation With Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0619
Abstract: Importance Lynch syndrome is caused by dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovarian, and other cancers through inactivation of the cellular mismatch repair system. Lynch syndrome–associated cancers are amenable to surveillance… read more here.
Keywords: surveillance; age; endometrial cancer; cancer ... See more keywords
Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12422
Abstract: Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in fibroblast growth factor receptor 2… read more here.
Keywords: bcl; death; endometrial cancer; cell death ... See more keywords
The feasibility study on the generalization of deep learning dose prediction model for volumetric modulated arc therapy of cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13583
Abstract: Abstract Purpose To develop a 3D‐Unet dose prediction model to predict the three‐dimensional dose distribution of volumetric modulated arc therapy (VMAT) for cervical cancer and test the dose prediction performance of the model in endometrial… read more here.
Keywords: cervical cancer; endometrial cancer; dose prediction; model ... See more keywords
Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1445
Abstract: Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic… read more here.
Keywords: cross disease; endometriosis endometrial; evidence; genetic correlation ... See more keywords
Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2956
Abstract: Endometrial cancer (EC) is a fatal female reproductive tumor. Bioinformatic tools are increasingly developed to screen out molecular targets related to EC. In this study, GSE17025 and GSE40032 were obtained from Gene Expression Omnibus (GEO).… read more here.
Keywords: analysis; identification aberrantly; aberrantly methylated; endometrial cancer ... See more keywords
Establishment and validation of a prognostic nomogram based on a novel five‐DNA methylation signature for survival in endometrial cancer patients
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3576
Abstract: This study aimed to explore the prognostic role of DNA methylation pattern in endometrial cancer (EC) patients. read more here.
Keywords: cancer; cancer patients; dna methylation; endometrial cancer ... See more keywords
Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: A population‐based analysis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3861
Abstract: Women with endometrial cancer (EC) have favorable prognoses, leaving them vulnerable to the development of second primary cancers (SPCs). We investigated the SPC risk and survival outcomes among EC patients treated with surgery alone in… read more here.
Keywords: second primary; increased risk; endometrial cancer; surgery alone ... See more keywords
RNA‐seq and ATAC‐seq analysis of CD163 + macrophage‐induced progestin‐insensitive endometrial cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5396
Abstract: Progestins are used as fertility‐sparing regimens for young patients with stage 1A endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH). CD163+ macrophages promote estrogen‐dependent EEC development, but whether they induce progestin insensitivity remains unclear.… read more here.
Keywords: endometrial cancer; rna seq; cd163; seq atac ... See more keywords
Causes of death in endometrial cancer survivors: A Surveillance, Epidemiology, and End Result–based analysis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5804
Abstract: Increasing attention has been paid to the survival of endometrial cancer (EC) patients, but the non‐cancer causes of death from EC are rarely reported. This study primarily aimed to investigate the non‐cancer causes of death… read more here.
Keywords: endometrial cancer; cancer; death endometrial; causes death ... See more keywords
Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.967
Abstract: Urocortin (UCN1) peptide shares structural and functional homology with corticotropin‐releasing factor (CRF). UCN1 is significantly reduced in endometrial adenocarcinoma compared to healthy controls. However, there are no data which evaluate the effects of UCN1 in… read more here.
Keywords: crfr2; effect; migration; endometrial cancer ... See more keywords