T cell-inflamed phenotype and increased Foxp3 expression in infiltrating T-cells of mismatch-repair deficient endometrial cancers
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0172-x
Abstract: Mismatch repair-deficient endometrial cancers have a high somatic mutation burden, suggesting that patients with these tumors may benefit from immunotherapy. Elucidating the immune suppressive mechanisms of mismatch repair-deficient endometrial cancers is fundamental to developing future… read more here.
Keywords: immune; deficient endometrial; repair deficient; mismatch repair ... See more keywords
Mirenas against malignancy: an alternative to operative management
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2018.1444395
Abstract: Abstract Background: Complex atypical hyperplasia is a recognised precursor to endometrial cancer, the most common gynaecological cancer of the Western World, with hysterectomy being the first line of management. With the increasing elderly population size… read more here.
Keywords: treatment; management; malignancy; mirena coil ... See more keywords
HER2 Gene Protein Assay: A Robust Tool for Evaluating HER2 Status and Intratumoral Heterogeneity in Endometrial Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac179
Abstract: OBJECTIVES Human epidermal growth factor receptor 2 (HER2) status in endometrial cancer is usually determined by immunohistochemistry and/or in situ hybridization. We employed a novel HER2 gene protein assay (GPA) to simultaneously assesses HER2 gene… read more here.
Keywords: her2 status; her2 gene; her2; endometrial cancers ... See more keywords
Abstract 1242: Ornithine decarboxylase as a therapeutic target in endometrial cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1242
Abstract: Endometrial cancer is the 4th most common cancer and the 6th deadliest cancer in US women. The American Cancer Society estimates there will be 60,050 new endometrial cancers in 2016, an increase of more than… read more here.
Keywords: ornithine decarboxylase; endometrial cancer; cancer; endometrial cancers ... See more keywords
Abstract 6522: Improved detection of low frequency mutations in ovarian and endometrial cancers by utilizing a highly accurate sequencing platform
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6522
Abstract: Ovarian and endometrial cancers come within the top-4 for incident cancers as well as deaths in North American women. Cure rates have not improved in 30 years as high-grade subtypes continue to be diagnosed in… read more here.
Keywords: ovarian endometrial; endometrial cancers; accurate sequencing; highly accurate ... See more keywords
The Role of Statins in the Prevention of Ovarian and Endometrial Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-22-0374
Abstract: Ovarian and endometrial cancers are the most common gynecologic malignancies and emerging evidence suggests that lipid metabolism and subsequent inflammation are important etiologic factors for both tumors. Statins (HMG-CoA reductase inhibitors) are the most widely… read more here.
Keywords: ovarian endometrial; endometrial cancers; role; prevention ... See more keywords
Results of a phase 2 trial of ribociclib and letrozole in patients with either relapsed estrogen receptor (ER)-positive ovarian cancers or relapsed ER-positive endometrial cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.5510
Abstract: 5510 Background: Single agent aromatase inhibitor (AI) therapy is associated with limited clinical activity in ovarian cancer (OC) and endometrial cancers (EC). AI therapy was associated with a progression free survival (PFS) at 12 weeks… read more here.
Keywords: relapsed positive; ribociclib letrozole; endometrial cancers; trial ... See more keywords
Effects of nivolumab alone or combination with molecular targeting agents for recurrent and refractory endometrial cancers with biomarker analyses.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e17124
Abstract: e17124 Background: The immunotherapy drug, nivolumab, is now approved for several metastatic cancers, and has resulted in responses previously not seen with these cancers. Molecular targeting agents, such as mammalian target of rapamycin (mTOR) inhibitor,… read more here.
Keywords: histology; targeting agents; molecular targeting; alone combination ... See more keywords
Chemoresistance and targeted therapies in ovarian and endometrial cancers
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14021
Abstract: Gynecological cancers are known for being very aggressive at their advanced stages. Indeed, the survival rate of both ovarian and endometrial cancers is very low when diagnosed lately and the success rate of current chemotherapy… read more here.
Keywords: chemoresistance; chemoresistance targeted; ovarian endometrial; therapies ovarian ... See more keywords
Histo-molecular features of high-grade endometrial cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Minerva medica"
DOI: 10.23736/s0026-4806.20.07082-2
Abstract: High-grade endometrial cancers (ECs) are an aggressive subset of ECs accounting for 70-80% of EC-related deaths. Currently, staging surgery together with chemotherapy or radiotherapy is the main treatment strategy for these cancers. The widespread use… read more here.
Keywords: high grade; molecular features; features high; grade endometrial ... See more keywords
Shared sex hormone metabolism-related gene prognostic index between breast and endometrial cancers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1126862
Abstract: Aims As sex hormone-dependent tumors, it remains to be clarified whether there is a common genetic signature and its value between breast and endometrial cancers. The aim of this study was to establish the shared… read more here.
Keywords: metabolism; endometrial cancers; sex hormone; sex ... See more keywords