Significant risk of occult cancer in complex non-atypical endometrial hyperplasia
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-019-05299-2
Abstract: In the 2014 WHO classification of endometrial hyperplasia (EH), complex EH is lumped together with simple EH in the benign category of non-atypical EH. To assess the risk of coexistent cancer in complex EH and… read more here.
Keywords: cancer complex; risk; non atypical; cancer ... See more keywords
Long-term outcome of postmenopausal women with proliferative endometrium on endometrial sampling.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.06.045
Abstract: INTRODUCTION Proliferative endometrium has been reported in 15% of endometrial biopsies of women 50 and older. In contrary to endometrial hyperplasia, proliferative endometrium has not been associated with risk of endometrial cancer. We sought to… read more here.
Keywords: women proliferative; proliferative endometrium; endometrium; cancer ... See more keywords
2921 Trends in Endometrial Hyperplasia Over the Past Decade – Is It on the Increase?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Minimally Invasive Gynecology"
DOI: 10.1016/j.jmig.2019.09.493
Abstract: Study Objective Atypical Hyperplasia carries a 30% risk of developing endometrial cancer over 20 years. Endometrial cancer has increased by 54% since the 1998. Overall hysterectomy rates are falling, and obesity increases. We reviewed 3… read more here.
Keywords: hyperplasia without; surveillance; without atypia; increase ... See more keywords
Conservative Treatment for Endometrial Hyperplasia with Atypia and Grade 1 Endometrioid Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Minimally Invasive Gynecology"
DOI: 10.1016/j.jmig.2020.08.146
Abstract: Study Objective to determine the oncologic and reproductive outcomes in women with endometrial hyperplasia with atypia (AH) or stage IA grade 1 endometrioid endometrial cancer (EEC) undergoing medical management with high-dose progestin therapy in our… read more here.
Keywords: endometrioid endometrial; treatment; conservative treatment; grade endometrioid ... See more keywords
Robotic-assisted laparoscopic hysterectomy for endometrial hyperplasia or grade 1 endometrial adenocarcinoma: a ten-year, single centre experience.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2020.10.016
Abstract: OBJECTIVE To describe the outcomes of patients undergoing robotic-assisted laparoscopic hysterectomy for grade-1 endometroid endometrial cancer or endometrial hyperplasia at our centre. METHODS Retrospective chart review was completed for 160 patients who underwent robotic-assisted laparoscopic… read more here.
Keywords: laparoscopic hysterectomy; rate; robotic assisted; assisted laparoscopic ... See more keywords
The impact of the additional metformin to the treatment of endometrial hyperplasia without atypia in addition to progesterone in a randomized fashion, a placebo-controlled, double blind clinical trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of gynecology obstetrics and human reproduction"
DOI: 10.1016/j.jogoh.2020.101863
Abstract: OBJECTIVE Endometrial hyperplasia (EH) is a premalignant neoplasm. Most recently, metformin has been suggested as an adjuvant medication for treating of EH with better outcome. Recent evidence has suggested that metformin has anticancer activity by… read more here.
Keywords: treatment; without atypia; group; metformin ... See more keywords
Levonorgestrel-releasing intrauterine system versus oral medroxyprogesterone acetate in infertile women with endometrial hyperplasia without atypia.
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2021.08.022
Abstract: RESEARCH QUESTION How does use of a levonorgestrel-releasing intrauterine system (LNG-IUS) in infertile women with endometrial hyperplasia without atypia affect endometrial hyperplasia regression and pregnancy rates compared with oral medroxyprogesterone acetate (MPA)? DESIGN This prospective… read more here.
Keywords: hyperplasia without; lng ius; infertile women; endometrial hyperplasia ... See more keywords
The regulation of Hh/Gli1 signaling cascade involves Gsk3β- mediated mechanism in estrogen-derived endometrial hyperplasia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06370-1
Abstract: The present study was undertaken to explore the functional involvement of Hh signaling and its regulatory mechanism in endometrial hyperplasia. Differential expression of Hh signaling molecules i.e., Ihh, Shh, Gli1 or Gsk3β was observed in… read more here.
Keywords: mechanism; gli1; estrogen; expression ... See more keywords
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70773-w
Abstract: Endometrial hyperplasia (EH) is a condition where uterine endometrial glands show excessive proliferation of epithelial cells that may subsequently progress into endometrial cancer (EC). Modern lifestyle disorders such as obesity, hormonal changes and hyperinsulinemia are… read more here.
Keywords: wdr13; knockout female; wdr13 knockout; mice ... See more keywords
Role of hysteroscopy during conservative management of atypical endometrial hyperplasia and early-stage endometrial cancer in patients who desire pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2022.2152656
Abstract: Abstract Twenty-five percent of cases of endometrial cancer appear in women with unfulfilled reproductive desires. An adequate selection of patients and a close hysteroscopic follow-up to monitor the endometrial response to the levonorgestrel-releasing intrauterine system… read more here.
Keywords: endometrial cancer; conservative management; endometrial hyperplasia; cancer ... See more keywords
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac101
Abstract: Abstract Loss of heterozygosity and promoter hypermethylation of APC is frequently observed in human endometrial cancer, which is the most common gynecological cancer in the USA, but its carcinogenic driver status in the endometrial epithelium… read more here.
Keywords: endometrial hyperplasia; loss; mice; epithelial cells ... See more keywords